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Processes
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Model Lipid Membranes
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Model Lipid Membranes

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 6977

Special Issue Editors

Dr. Arkadiusz Matwijczuk

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Guest Editor
Department of Biophysics, Faculty of Environmental Biology, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
Interests: crystal growth; light scattering; biophysics; fluorescence spectroscopy; hydrogen bonding; intermolecular interactions; photophysics; spectral analysis; fluorescence; thiadiazoles; coumarins; experimental physics; lipids; time correlated single photon counting; dye chemistry; ions; FTIR-RAMAN; solvent effect; proton transfer; TICT, ESIPT, AIE
Special Issues, Collections and Topics in MDPI journals
Dr. Dariusz Karcz

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Guest Editor
Department of Chemical Technology and Environmental Analytics (C1), Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, Poland
Interests: 1,3,4-thiadiazole; coumarin; metal complexes; synthesis; structural modification; molecular spectroscopy; structural elucidation, NMR; IR; Uv-vis; fluorescence; sensors; biological activity; antifungal; antibacterial; antineurodegenerative
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biological membranes and especially cell membranes (both internal and external) constitute the physical barriers which protect cells from the external environment and separate cells from one another. In addition, these membranes are often the arena for plethora of life-support processes occurring at the cellular level. The research on model lipid membranes is multidisciplinary and closely related to contemporary biophysics, photophysics, photochemistry, pharmaceutical and medicinal sciences.

This Special Issue is dedicated to research on model lipid membranes and various aspects of their practical application. Therefore, we particularly welcome contributions from research on mono- and dual-layer lipid systems with various modifications, including small molecules. We strongly encourage the submissions consisting of investigations into the membrane permeability of small molecules, such as sterols, and particularly those which may serve as vehicles for transporting potential therapeutic agents. Investigations into nanostructures and mixed lipids (liposomes) are also welcome. The contributions should consist of research carried out with use of various spectroscopic techniques, including electronic absorption, fluorescence emission (both steady state and time resolved), molecular electronic transition spectroscopy, fluorescence lifetimes, FT-IR and Raman spectroscopy, Circular Dichroism (CD), Differential Scanning Calorimetry (DSC), NMR and NMR imaging spectroscopy, SPR, FLIM, Confocal, Fluorescence Microscopy and other related techniques. Contributions consisting of theoretical studies such as quantum-mechanical calculations (DFT) or molecular dynamics are also welcome.

Dr. Arkadiusz Matwijczuk
Dr. Dariusz Karcz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Model lipid membranes
  • Lipid monolayers and bilayers
  • Liposomal systems
  • Molecular spectroscopy (electronic absorption and emission, fluorescence lifetime, molecular electronic transition spectroscopy, FT-IR and Raman spectroscopy, circular dichroism (CD), Differential Scanning Calorimetry (DSC), NMR and NMR imaging spectroscopy, SPR, FLIM, Confocal Microsopy, Fluorescence Microsopy
  • Lipid mixes (various lipids) and modifications with sterol additives
  • Small molecule additives (various small molecules e.g., thiadiazoles, coumarins, Hybrid systems of small molecules, molecular sensors and other compounds which change their physiochemical properties upon the interactions with lipid system)
  • Various nanoparticle-based additives
  • Molecular dynamics of lipid membranes and small molecule-modified lipid membranes
  • Membrane peptides and proteins

Published Papers (2 papers)

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Research

11 pages, 1550 KiB  
Article
Sulfatide-Rich Liposome Uptake by a Human-Derived Neuroblastoma Cell Line
by Daniel Arroyo-Ariza, Elizabeth Suesca, Chad Leidy and John M. Gonzalez
Processes 2020, 8(12), 1615; https://0-doi-org.brum.beds.ac.uk/10.3390/pr8121615 - 08 Dec 2020
Cited by 2 | Viewed by 2117
Abstract
Liposomes are bilayer membrane vesicles that can serve as vehicles for drug delivery. They are a good alternative to free drug administration that provides cell-targeted delivery into tumors, limiting the systemic toxicity of chemotherapeutic agents. Previous results from our group showed that an [...] Read more.
Liposomes are bilayer membrane vesicles that can serve as vehicles for drug delivery. They are a good alternative to free drug administration that provides cell-targeted delivery into tumors, limiting the systemic toxicity of chemotherapeutic agents. Previous results from our group showed that an astrocytoma cell line exhibits selective uptake of sulfatide-rich (SCB) liposomes, mediated by the low-density lipoprotein receptor (LDL-R). The goal of this study was to assess the uptake of liposomes in a neuroblastoma cell line. For this purpose, we used two types of liposomes, one representing a regular cell membrane (DOPC) and another rich in myelin components (SCB). An astrocytoma cell line was used as a control. Characterization of liposome uptake and distribution was conducted by flow cytometry and fluorescence microscopy. Similar levels of LDL-R expression were found in both cell lines. The uptake of SCB liposomes was higher than that of DOPC liposomes. No alterations in cell viability were found. SCB liposomes were located near the cell membrane and did not colocalize within the acidic cellular compartments. Two endocytic pathway inhibitors did not affect the liposome uptake. Neuroblastoma cells exhibited a similar uptake of SCB liposomes as astrocytoma cells; however, the pathway involved appeared to be different than the hypothesized pathway of LDL-R clathrin-mediated endocytosis. Full article
(This article belongs to the Special Issue Model Lipid Membranes)
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29 pages, 4151 KiB  
Article
Manipulation of Culture Conditions: Tool for Correlating/Improving Lipid and Carotenoid Production by Rhodotorula glutinis
by Nora Elfeky, Mostafa Elmahmoudy and Yongming Bao
Processes 2020, 8(2), 140; https://0-doi-org.brum.beds.ac.uk/10.3390/pr8020140 - 21 Jan 2020
Cited by 16 | Viewed by 3988
Abstract
The coproduction of lipid and carotenoid by red yeasts in one cycle is more convenient and economical for the industrial sectors, while the kinetics correlation between both products under different culture conditions has been scarcely studied. This study is aiming to correlate the [...] Read more.
The coproduction of lipid and carotenoid by red yeasts in one cycle is more convenient and economical for the industrial sectors, while the kinetics correlation between both products under different culture conditions has been scarcely studied. This study is aiming to correlate the impact of different carbon sources, carbon to phosphorus ratio (C/P), temperature, aeration, pH, and metals on dry cell weight, lipid (GC and fluorescence microscope), and carotenoid (HPLC) production by Rhodotorula glutinis, and applying a novel feeding approach using a 5 L bioreactor to enhance carotenoid and unsaturated fatty acid production by R. glutinis. Whatever the culture condition is, the reversible correlation between lipid and carotenoid production was detected. Remarkably, when adding 0.1 mM BaCl2, cellular lipid was significantly increased 14% more than the control, with 79.3% unsaturated fatty acid (46% C18:2 and C18:3) and 50% γ-carotene, while adding 1 mM NiSO4, cellular carotenoid was enhanced around 53% than the control (torulene 88%) with 81% unsaturated fatty acid (61% oleic acid). Excitingly, 68.8 g/l biomass with 41% cellular lipid (79% unsaturated fatty acid) and 426 µgpigment/gdcw cellular carotenoid (29.3 mg/L) (71% torulene) were obtained, when the pH-temperature dual controlled process combined with metallo-sulfo-phospho-glucose feeding approach in the 5 L bioreactor during the accumulation phase was conducted. This is the first study on the kinetic correlation between lipid and carotenoid under different C/P ratio and the dual effect of different metals like NiSO4 on lipid and carotenoid production by red oleaginous yeasts, which in turn significant for enhancing the coproduction of lipid and carotenoid by R. glutinis. Full article
(This article belongs to the Special Issue Model Lipid Membranes)
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