Mechanisms of Enzymatic Reactions

Dear Colleagues,

The production of fine chemicals through enzyme catalysis is an attractive alternative to environmentally costly organic syntheses due to the possibility of performing the reactions of interest in aqueous solution and at mild temperatures. Although the substrate scope of these reactions can be enhanced through protein engineering and enzyme evolution, efficient interventions require that any changes introduced into the enzyme structure do not affect its ability to catalyze their reactions. A precise understanding of the enzymatic catalytic mechanism is therefore highly desirable both for fundamental reasons and for the eventual development of better enzyme variants.

This Special Issue will be focused on the experimental and computational study of enzymatic reaction mechanisms. We welcome submissions addressing all aspects of enzymology, including (but not limited to) traditional enzyme kinetics, the characterization of elusive intermediates, the influence of active site mutagenesis in reaction outcomes, quantum-chemical studies of putative reaction mechanisms, and molecular dynamics studies of substrate binding/product release.

Prof. Dr. Pedro Silva
Guest Editor

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• active sites
• transition states
• enzyme mechanisms
• cofactors
• green chemistry