Special Issue "Clinical and Molecular Analytic in Neuro-Oncology"

A special issue of Tomography (ISSN 2379-139X). This special issue belongs to the section "Cancer Imaging".

Deadline for manuscript submissions: 30 June 2022.

Special Issue Editors

Dr. Alessandro Pesce
E-Mail Website
Guest Editor
Neurosurgery Division, Santa Maria Goretti Hospital, Via Guido Reni, 04100 Latina, Italy
Interests: gliobastoma; intrinsic brain tumors; spinal intramedullary tumors
Prof. Dr. Angelo Pompucci
E-Mail Website
Guest Editor
Santa Maria Goretti Hospital, 95121 Latina, Italy
Interests: spinal intramedullary tumors; primary brain tumors
Prof. Dr. Maurizio Salvati
E-Mail Website
Guest Editor
Istituto Neurologico Mediterraneo Neuromed, 30085 Pozzill, Italy
Interests: glioblastoma; primary brain tumors; low-grade gliomas; spinal intramedullary tumors
Prof. Dr. Alessandro Frati
E-Mail Website
Guest Editor
Neurosurgery Division, Human Neurosciences Department, Sapienza University, 00135 Roma, Italy
Interests: gliobastoma; intrinsic brain tumors; spinal intramedullary tumors; eloquent area neurosurgery
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Special Issue Information

Dear Colleagues, 

In the last years, great steps beyond in the understanding of the molecular pathophysiology of both primary and metastatic brain tumors have been made, thus producing a notable improvement of  their clinical management. The role of the 1p/19q translocation along with the IDH mutation status have been unanimously recognized and acknowledged as key factor for defining the biological behavior of the lesions, as well as MGMT methylation status has been extensively investigated as predictor of the treatment response in the primary brain neoplasms.  Such specific molecular patterns have been even associated to precise radiological appearances and clinical phenotypes, such as for instance in the more extensive expected neuropsychological impairment in patients suffering from IDH wild type Diffuse Astrocytomas in respect to their mutated counterparts. In Brain Metastases (BM) research, a wave of molecular findings has renewed our old conception of the “metastatic phenotype”, transforming it in a more wide and complex network of interactions between cytokines, microenvironment and adhesions molecules. The advanced Neuroimaging research is currently providing an increasing amount of evidences concerning the radiological implications of the molecular phenotypes of the lesions; this is not only particularly significant for PBTs and BMs, but for intracranial meningiomas and lymphomas either.

Therefore, with pleasure, we invite investigators to contribute to this Special Issue with original research articles, review articles and meta-analysis articles focusing on the current knowledge of the molecular pathogenesis of the Brain Tumors, with special regard to their clinical, radiological and surgical implications for the Neuro-oncologic practice.

Dr. Alessandro Pesce
Prof. Dr. Angelo Pompucci
Prof. Dr. Maurizio Salvati
Prof. Dr. Alessandro Frati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Tomography is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Glioblastoma
  • Primary Brain Tumors
  • Low-grade gliomas
  • Spinal intramedullary tumors
  • Brain metastases
  • MRI Spectroscopy
  • Molecular analytic in Neuro-oncology
  • Advanced Neuroimaging in Neuro-oncology

Published Papers (1 paper)

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Is It Worth Considering Multicentric High-Grade Glioma a Surgical Disease? Analysis of Our Clinical Experience and Literature Review
Tomography 2021, 7(4), 523-532; https://0-doi-org.brum.beds.ac.uk/10.3390/tomography7040045 - 05 Oct 2021
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Introduction. The simultaneous presence of multiple foci of high-grade glioma is a rare condition with a poor prognosis. By definition, if an anatomical connection through white matter bundles cannot be hypothesized, multiple lesions are defined as multicentric glioma (MC); on the other hand, [...] Read more.
Introduction. The simultaneous presence of multiple foci of high-grade glioma is a rare condition with a poor prognosis. By definition, if an anatomical connection through white matter bundles cannot be hypothesized, multiple lesions are defined as multicentric glioma (MC); on the other hand, when this connection exists, it is better defined as multifocal glioma (MF). Whether surgery can be advantageous for these patients has not been established yet. The aim of our study was to critically review our experience and to compare it to the existing literature. Materials and Methods. Retrospective analysis of patients operated on for MC HGG in two Italian institutions was performed. Distinction between MC and MF was achieved through revision of MR FLAIR images. Clinical and radiological preoperative and postoperative data were analyzed through chart revision and phone interviews. The same data were extracted from literature review. Univariate and multivariate analyses were conducted for the literature review only, and the null hypothesis was rejected for a p-value ≥ 0.05. Results. Sixteen patients met the inclusion criteria; male predominance and an average age of 66.5 years were detected. Sensory/motor deficit was the main onset symptom both in clinical study and literature review. A tendency to operate on the largest symptomatic lesion was reported and GTR was reached in the majority of cases. GBM was the histological diagnosis in most part of the patients. OS was 8.7 months in our series compared to 7.5 months from the literature review. Age ≤ 70 years, a postoperative KPS ≥ 70, a GTR/STR, a second surgery and adjuvant treatment were shown to be significantly associated with a better prognosis. Pathological examination revealed that MC HGG did not originate by LGG. Conclusions. MC gliomas are rare conditions with high malignancy and a poor prognosis. A maximal safe resection should be attempted whenever possible, especially in younger patients with life-threatening large mass. Full article
(This article belongs to the Special Issue Clinical and Molecular Analytic in Neuro-Oncology)
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