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Toxics
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Endocrine Disrupting Chemicals and Female Reproduction
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Endocrine Disrupting Chemicals and Female Reproduction

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 4932

Special Issue Editor

Prof. Dr. Eui-Bae Jeung

E-Mail Website
Guest Editor
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
Interests: reproductive toxicology; endocrine disruptors; animal alternative tests; guidelines of toxicology; calcium metabolism; steroid receptors; stem cells in pharmacological and toxicological test
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endocrine disruptors, also referred to as hormonally active agents, endocrine-disrupting chemicals (EDCs), or endocrine-disrupting compounds, are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause various diseases such as cancer, obesity, hypertension, and birth defects. It has been known that EDCs also increase the risk of female reproductive diseases such as endometriosis, breast cancer, and ovarian cancer. In addition, EDCs can affect the function and physiology of the reproductive system.

This Special Issue of Toxics will provide new insights into the correlation between EDCs and female reproduction and its related diseases, excavating our understanding on how they induce the adverse effects.

We are pleased to invite you to contribute to this Special Issue which aims to investigate topics related to:

  • The risk assessment of EDCs on female reproductive system;
  • The association between EDCs and reproductive diseases;
  • The mechanism of EDCs;
  • The toxicity testing and biomonitoring of EDCs in reproductive tissues;
  • The discovery of new biomarker for risk assessment.

Prof. Dr. Eui-Bae Jeung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

12 pages, 2307 KiB  
Article
Mitochondrial Toxic Effects of Antiepileptic Drug Valproic Acid on Mouse Kidney Stem Cells
by Minsu Lee, Changhwan Ahn, KangMin Kim and Eui-Bae Jeung
Toxics 2023, 11(5), 471; https://0-doi-org.brum.beds.ac.uk/10.3390/toxics11050471 - 20 May 2023
Viewed by 1169
Abstract
Valproic acid (VPA) is a histone deacetylase inhibitor that is used mainly as an antiepileptic and anticonvulsant drug. The side effects of VPA usually appears as hepatic injury and various metabolic disorders. On the other hand, it is rarely reported to cause kidney [...] Read more.
Valproic acid (VPA) is a histone deacetylase inhibitor that is used mainly as an antiepileptic and anticonvulsant drug. The side effects of VPA usually appears as hepatic injury and various metabolic disorders. On the other hand, it is rarely reported to cause kidney injury. Despite the many studies on the influence of VPA exposure on the kidneys, the specific mechanism remains unclear. This study examined the changes after VPA treatment to the mouse kidney stem cells (mKSCs). VPA triggers an increase in mitochondrial ROS, but there was no change in either mitochondrial membrane potential or the mitochondrial DNA copy number in mKSCs. The VPA treatment increased the mitochondrial complex III but decreased complex V significantly compared to the DMSO treatment as a control. The inflammatory marker (IL-6) and the expression of the apoptosis markers (Caspase 3) and were increased by VPA. In particular, the expression of the podocyte injury markers (CD2AP) was increased significantly. In conclusion, VPA exposure has adverse effects on mouse kidney stem cells. Full article
(This article belongs to the Special Issue Endocrine Disrupting Chemicals and Female Reproduction)
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13 pages, 3463 KiB  
Article
Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats
by Jimin Lee, Kangmin Kim, Seon-Mi Park, Jin-Sook Kwon and Eui-Bae Jeung
Toxics 2023, 11(4), 302; https://0-doi-org.brum.beds.ac.uk/10.3390/toxics11040302 - 25 Mar 2023
Viewed by 1651
Abstract
The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by various routes and affect the reproductive system. Exposure to these [...] Read more.
The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by various routes and affect the reproductive system. Exposure to these chemicals can cause problems with the reproductive process, from egg ovulation to implantation, or cause female reproductive diseases. These reproductive problems cause infertility. Decamethylcyclopentasiloxane (D5) is used for lubrication in silicone polymers, households, and personal care products. In the case of D5, it is discharged through factory wastewater and can bioaccumulate. Therefore, it accumulates in the human body. In this study, D5 was administered orally for four weeks to determine the effects of D5 on the reproductive process. As a result, D5 increases the number of follicles in the ovary and suppresses the expression of genes related to the growth of follicles. In addition, it increases the gonadotropin hormone, inducing estradiol enhancement and progesterone reduction. Because of these changes in the reproductive system when exposed to D5, the industry should reconsider using D5. Full article
(This article belongs to the Special Issue Endocrine Disrupting Chemicals and Female Reproduction)
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15 pages, 3002 KiB  
Article
Effects of Sodium Arsenite on the Myocardial Differentiation in Mouse Embryonic Bodies
by SunHwa Jeong, Changhwan Ahn, Jin-Sook Kwon, KangMin Kim and Eui-Bae Jeung
Toxics 2023, 11(2), 142; https://0-doi-org.brum.beds.ac.uk/10.3390/toxics11020142 - 01 Feb 2023
Cited by 2 | Viewed by 1667
Abstract
Arsenic in inorganic form is a known human carcinogen; even low levels of arsenic can interfere with the endocrine system. In mammalian development, arsenic exposure can cause a malformation of fetuses and be lethal. This study examined the effects of sodium arsenite (SA) [...] Read more.
Arsenic in inorganic form is a known human carcinogen; even low levels of arsenic can interfere with the endocrine system. In mammalian development, arsenic exposure can cause a malformation of fetuses and be lethal. This study examined the effects of sodium arsenite (SA) as the inorganic form of arsenic in embryonic bodies (EBs) with three germ layers in the developmental stage. This condition is closer to the physiological condition than a 2D cell culture. The SA treatment inhibited EBs from differentiating into cardiomyocytes. A treatment with 1 μM SA delayed the initiation of beating, presenting successful cardiomyocyte differentiation. In particular, mitochondria function analysis showed that SA downregulated the transcription level of the Complex IV gene. SA increased the fission form of mitochondrion identified by the mitochondria number and length. In addition, a treatment with D-penicillamine, an arsenic chelator, restored the beat of EBs against SA, but not mitochondrial dysfunction. These findings suggest that SA is a toxicant that induces mitochondrial damage and interferes with myocardial differentiation and embryogenesis. This study suggests that more awareness of SA exposure during pregnancy is required because even minuscule amounts have irreversible adverse effects on embryogenesis through mitochondria dysfunction. Full article
(This article belongs to the Special Issue Endocrine Disrupting Chemicals and Female Reproduction)
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