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Endocrine Disruptors Exposure and Human Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2288

Special Issue Editor


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Guest Editor
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea
Interests: reproductive toxicology; endocrine disruptors; animal alternative tests; guidelines of toxicology; calcium metabolism; steroid receptors; stem cells in pharmacological and toxicological test
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Special Issue Information

Dear Colleagues,

Endocrine disruptors (EDs) are environmental chemicals that interfere with the endocrine systems and adversely affect hormone balance or disrupt normal function of organs that hormones regulate or modulate, leading to detrimental effects in reproductive and developmental processes. Humans and animals come into contact with EDs through a variety of routes, including consumption of food and water, through the skin, by inhalation, and by transfer from mother to fetus across the placenta or mother to infant via lactation. Over the past few decades, the regulation of EDs has been debated among scientists, physicians, regulators, and the public. Key elements for the regulation of EDs are in process, and important discussions are ongoing, especially with regard to the establishment of criteria for the identification of endocrine disrupting substances. In this Special issue, recent progress in all aspects of EDs will be proposed for research, guiding the understanding of EDs. The research will give specific ways in which science can be employed for human health.

The aim of this Special Issue is to provide a forum to collect most recent progress in all aspects of EDs and their impacts on human health, to discuss possible ways forward, and to increase the level of knowledge and competence. Contributions to both animal models and/or humans, as well as to alternative tools, are encouraged, to shed light on the development of new hypotheses about endocrine disruptors.

Prof. Dr. Eui-Bae Jeung
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • endocrine disruptors
  • environmental chemicals
  • hormones
  • epigenetics

Published Papers (2 papers)

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Research

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17 pages, 3809 KiB  
Communication
The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes
by Andrea Di Credico, Giulia Gaggi, Ines Bucci, Barbara Ghinassi and Angela Di Baldassarre
Int. J. Mol. Sci. 2023, 24(19), 15018; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241915018 - 09 Oct 2023
Cited by 2 | Viewed by 994
Abstract
The present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals leach from plastic, and when ingested through contaminated food and water, they interfere with endogenous hormone signaling, causing various diseases. While [...] Read more.
The present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals leach from plastic, and when ingested through contaminated food and water, they interfere with endogenous hormone signaling, causing various diseases. While the ability of BPs and PFs to cross the placental barrier and accumulate in fetal serum has been documented, the exact consequences for human development require further elucidation. The present research work explored the effects of combined exposure to BPs (BPA or BPS) and PFs (PFOS and PFOA) on human placenta (fetal membrane mesenchymal stromal cells, hFM-MSCs) and amniotic fluid (hAFSCs)-derived stem cells. The effects of the xenobiotics were assessed by analyzing cell proliferation, mitochondrial functionality, and the expression of genes involved in pluripotency and epigenetic regulation, which are crucial for early human development. Our findings demonstrate that antenatal exposure to BPs and/or PFs may alter the biological characteristics of perinatal stem cells and fetal epigenome, with potential implications for health outcomes at birth and in adulthood. Further research is necessary to comprehend the full extent of these effects and their long-term consequences. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure and Human Health)
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Review

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16 pages, 1689 KiB  
Review
Effects of Pharmaceutical Substances with Obesogenic Activity on Male Reproductive Health
by Caio Mascarenhas, Ana C. A. Sousa and Luís Rato
Int. J. Mol. Sci. 2024, 25(4), 2324; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms25042324 - 15 Feb 2024
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Abstract
Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. Substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for their ability to induce weight gain, [...] Read more.
Obesogens have been identified as a significant factor associated with increasing obesity rates, particularly in developed countries. Substances with obesogenic traits are prevalent in consumer products, including certain pharmaceuticals. Specific classes of pharmaceuticals have been recognized for their ability to induce weight gain, often accompanied by hormonal alterations that can adversely impact male fertility. Indeed, research has supplied evidence underscoring the crucial role of obesogens and therapeutic agents in the normal functioning of the male reproductive system. Notably, sperm count and various semen parameters have been closely linked to a range of environmental and nutritional factors, including chemicals and pharmacological agents exhibiting obesogenic properties. This review aimed to explore studies focused on analyzing male fertility parameters, delving into the intricacies of sperm quality, and elucidating the direct and adverse effects that pharmacological agents may have on these aspects. Full article
(This article belongs to the Special Issue Endocrine Disruptors Exposure and Human Health)
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