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Viruses
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Viruses versus Bacteria—Novel Approaches to Phage Therapy as a Tool...
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Viruses versus Bacteria—Novel Approaches to Phage Therapy as a Tool against Multidrug-Resistant Pathogens: Second Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Bacterial Viruses".

Deadline for manuscript submissions: 1 June 2024 | Viewed by 1252

Special Issue Editor

Dr. Mao Ye

E-Mail Website
Guest Editor
Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China
Interests: metaviromes; phage therapy; virus–host interactions; antibiotic resistance genes; virus auxiliary metabolic genes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the problem of antibiotic resistance has become increasingly serious, threatening the health of human beings, animals and plants. Efficient and environmentally friendly phage therapy is expected to be a powerful approach to prevent and control the spread of pathogens in the fields of health care, food safety and ecology. Viruses is dedicated to providing a platform for the discussion of viruses and virus–host interactions, antibiotic-resistant pathogens and phage therapy. Its core purpose is to bring together researchers across the environmental, public health, animal medicine, and food fields with common scientific objectives to explore the latest high-quality scientific knowledge on blocking the transmission of pathogens and reducing antimicrobial resistance via phage therapy.

Dr. Mao Ye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viruses
  • phage therapy
  • multidrug-resistant pathogens
  • virus–host interactions

Published Papers (1 paper)

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Research

20 pages, 3943 KiB  
Article
StM171, a Stenotrophomonas maltophilia Bacteriophage That Affects Sensitivity to Antibiotics in Host Bacteria and Their Biofilm Formation
by Ghadeer Jdeed, Vera Morozova, Yuliya Kozlova, Artem Tikunov, Tatyana Ushakova, Alevtina Bardasheva, Andrey Manakhov, Maria Mitina, Elena Zhirakovskaya and Nina Tikunova
Viruses 2023, 15(12), 2455; https://0-doi-org.brum.beds.ac.uk/10.3390/v15122455 - 18 Dec 2023
Viewed by 1085
Abstract
Stenotrophomonas maltophilia mainly causes respiratory infections that are associated with a high mortality rate among immunocompromised patients. S. maltophilia exhibits a high level of antibiotic resistance and can form biofilms, which complicates the treatment of patients infected with this bacterium. Phages combined with [...] Read more.
Stenotrophomonas maltophilia mainly causes respiratory infections that are associated with a high mortality rate among immunocompromised patients. S. maltophilia exhibits a high level of antibiotic resistance and can form biofilms, which complicates the treatment of patients infected with this bacterium. Phages combined with antibiotics could be a promising treatment option. Currently, ~60 S. maltophilia phages are known, and their effects on biofilm formation and antibiotic sensitivity require further examination. Bacteriophage StM171, which was isolated from hospital wastewater, showed a medium host range, low burst size, and low lytic activity. StM171 has a 44kbp dsDNA genome that encodes 59 open-reading frames. A comparative genomic analysis indicated that StM171, along with the Stenotrophomonas phage Suso (MZ326866) and Xanthomonas phage HXX_Dennis (ON711490), are members of a new putative Nordvirus genus. S. maltophilia strains that developed resistance to StM171 (bacterial-insensitive mutants) showed a changed sensitivity to antibiotics compared to the originally susceptible strains. Some bacterial-insensitive mutants restored sensitivity to cephalosporin and penicillin-like antibiotics and became resistant to erythromycin. StM171 shows strain- and antibiotic-dependent effects on the biofilm formation of S. maltophilia strains. Full article
(This article belongs to the Special Issue Viruses versus Bacteria—Novel Approaches to Phage Therapy as a Tool against Multidrug-Resistant Pathogens: Second Edition)
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