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Review

Association between Stress and the HPA Axis in the Atopic Dermatitis

1
Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
2
Citrus Valley Medical Center, West Covina, CA 91790, USA
3
Dermatology Service & Translational Research Unit (UIT), Hospital General Universitario de Ciudad Real, Ciudad Real 13005, Spain
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(10), 2131; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102131
Received: 1 September 2017 / Revised: 6 October 2017 / Accepted: 9 October 2017 / Published: 12 October 2017
The hypothalamic–pituitary–adrenal (HPA) axis is one of the body’s neuroendocrine networks that responds to psychological stress (PS). In the skin, there exists a peripheral HPA axis similar to the central axis. Glucocorticoids (GCs) are key effector molecules of the HPA axis and are essential for cutaneous homeostasis. Atopic dermatitis (AD) is a condition typically characterized by a chronic relapsing course that often results in PS. HPA dysfunction is present in AD patients by the decreased response of GCs elevation to stress as compared to those unaffected by AD. Nevertheless, in skin, acute PS activates several metabolic responses that are of immediate benefit to the host. During the acute phase of PS, increased endogenous GCs have been shown to provide benefit rather than by aggravating cutaneous inflammatory dermatoses. However, a chronic T helper cell type 2 (Th2) predominant cytokine profile acts as a negative feedback loop to blunt the HPA axis response in AD. In this article, we reviewed the role of CRF, pro-opiomelanocortin (POMC)-derived peptides, GCs of the HPA, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in AD, with a discussion of the pathogenetic mechanisms of inflammation and skin barrier functions, including antimicrobial defense, and their association with PS. View Full-Text
Keywords: atopic dermatitis; HPA axis; psychological stress; skin barrier; inflammation; glucocorticoid atopic dermatitis; HPA axis; psychological stress; skin barrier; inflammation; glucocorticoid
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MDPI and ACS Style

Lin, T.-K.; Zhong, L.; Santiago, J.L. Association between Stress and the HPA Axis in the Atopic Dermatitis. Int. J. Mol. Sci. 2017, 18, 2131. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102131

AMA Style

Lin T-K, Zhong L, Santiago JL. Association between Stress and the HPA Axis in the Atopic Dermatitis. International Journal of Molecular Sciences. 2017; 18(10):2131. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102131

Chicago/Turabian Style

Lin, Tzu-Kai, Lily Zhong, and Juan L. Santiago 2017. "Association between Stress and the HPA Axis in the Atopic Dermatitis" International Journal of Molecular Sciences 18, no. 10: 2131. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms18102131

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