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Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells

1
College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea
2
R&D Center, PSM Inc. Jungwon-gu, Seongnam-si, Gyeonggi-do 13207, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4556; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124556
Received: 18 May 2020 / Revised: 13 June 2020 / Accepted: 24 June 2020 / Published: 26 June 2020
Osteosarcoma is known to be one of the frequently occurring cancers in dogs. Its prognosis is usually very poor, with a high incidence of lung metastasis. Although radiation therapy has become a major therapeutic choice for canine osteosarcoma, the high costs and unexpected side effects prevent some patients from considering this treatment. Cold atmospheric plasma (CAP) is an ionized gas with high energy at low temperatures, and it produces reactive oxygen species that mediate many signaling pathways. Although many researchers have used CAP as an anticancer therapeutic approach in humans, its importance has been neglected in veterinary medicine. In this study, D-17 and DSN canine osteosarcoma cell lines were treated with CAP to observe its anticancer activity. By high-content screening and flow cytometry, CAP-treated cells showed growth arrest and apoptosis induction. Moreover, the osteosarcoma cells exhibited reduced migration and invasion activity when treated with CAP. Overall, CAP exerted an anticancer effect on canine osteosarcoma cell lines. CAP may have the potential to be used as a novel modality for treating cancer in veterinary medicine. View Full-Text
Keywords: canine osteosarcoma; cold atmospheric plasma; high-content screening; reactive oxygen species; metastasis canine osteosarcoma; cold atmospheric plasma; high-content screening; reactive oxygen species; metastasis
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MDPI and ACS Style

Lee, J.; Moon, H.; Ku, B.; Lee, K.; Hwang, C.-Y.; Baek, S.J. Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells. Int. J. Mol. Sci. 2020, 21, 4556. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124556

AMA Style

Lee J, Moon H, Ku B, Lee K, Hwang C-Y, Baek SJ. Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells. International Journal of Molecular Sciences. 2020; 21(12):4556. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124556

Chicago/Turabian Style

Lee, Jaehak, Hyunjin Moon, Bonghye Ku, Keunho Lee, Cheol-Yong Hwang, and Seung J. Baek 2020. "Anticancer Effects of Cold Atmospheric Plasma in Canine Osteosarcoma Cells" International Journal of Molecular Sciences 21, no. 12: 4556. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21124556

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