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Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

by 1 and 2,3,4,5,*
1
Department of Microbiology, Chitwan Medical College, Bharatpur 44200, Nepal
2
Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Oita 879-5593, Japan
3
Global Oita Medical Advanced Research Center for Health (GO-MARCH), Yufu, Oita 879-5593, Japan
4
Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX 77030, USA
5
Borneo Medical and Health Research Centre, Universiti Malaysia Sabah, Kota Kinabalu, Sabah 88400, Malaysia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7430; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197430
Received: 21 September 2020 / Revised: 6 October 2020 / Accepted: 6 October 2020 / Published: 8 October 2020
(This article belongs to the Special Issue Microbial Virulence Factors 2.0)
Helicobacter pylori causes persistent infection in the gastric epithelium of more than half of the world’s population, leading to the development of severe complications such as peptic ulcer diseases, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Several virulence factors, including cytotoxin-associated gene A (CagA), which is translocated into the gastric epithelium via the type 4 secretory system (T4SS), have been indicated to play a vital role in disease development. Although infection with strains harboring the East Asian type of CagA possessing the EPIYA-A, -B, and -D sequences has been found to potentiate cell proliferation and disease pathogenicity, the exact mechanism of CagA involvement in disease severity still remains to be elucidated. Therefore, we discuss the possible role of CagA in gastric pathogenicity. View Full-Text
Keywords: H. pylori; virulence factor; cag pathogenicity island; CagA; gastric cancer H. pylori; virulence factor; cag pathogenicity island; CagA; gastric cancer
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MDPI and ACS Style

Ansari, S.; Yamaoka, Y. Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity. Int. J. Mol. Sci. 2020, 21, 7430. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197430

AMA Style

Ansari S, Yamaoka Y. Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity. International Journal of Molecular Sciences. 2020; 21(19):7430. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197430

Chicago/Turabian Style

Ansari, Shamshul, and Yoshio Yamaoka. 2020. "Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity" International Journal of Molecular Sciences 21, no. 19: 7430. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21197430

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