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Biological Functions of HMGN Chromosomal Proteins

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
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Int. J. Mol. Sci. 2020, 21(2), 449; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020449
Received: 18 December 2019 / Revised: 2 January 2020 / Accepted: 8 January 2020 / Published: 10 January 2020
(This article belongs to the Special Issue HMG Proteins in Development and Disease)
Chromatin plays a key role in regulating gene expression programs necessary for the orderly progress of development and for preventing changes in cell identity that can lead to disease. The high mobility group N (HMGN) is a family of nucleosome binding proteins that preferentially binds to chromatin regulatory sites including enhancers and promoters. HMGN proteins are ubiquitously expressed in all vertebrate cells potentially affecting chromatin function and epigenetic regulation in multiple cell types. Here, we review studies aimed at elucidating the biological function of HMGN proteins, focusing on their possible role in vertebrate development and the etiology of disease. The data indicate that changes in HMGN levels lead to cell type-specific phenotypes, suggesting that HMGN optimize epigenetic processes necessary for maintaining cell identity and for proper execution of specific cellular functions. This manuscript contains tables that can be used as a comprehensive resource for all the English written manuscripts describing research aimed at elucidating the biological function of the HMGN protein family. View Full-Text
Keywords: HMGN proteins; chromatin; epigenetics; gene regulation; development HMGN proteins; chromatin; epigenetics; gene regulation; development
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MDPI and ACS Style

Nanduri, R.; Furusawa, T.; Bustin, M. Biological Functions of HMGN Chromosomal Proteins. Int. J. Mol. Sci. 2020, 21, 449. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020449

AMA Style

Nanduri R, Furusawa T, Bustin M. Biological Functions of HMGN Chromosomal Proteins. International Journal of Molecular Sciences. 2020; 21(2):449. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020449

Chicago/Turabian Style

Nanduri, Ravikanth, Takashi Furusawa, and Michael Bustin. 2020. "Biological Functions of HMGN Chromosomal Proteins" International Journal of Molecular Sciences 21, no. 2: 449. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21020449

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