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Article

Genetic Base of Behavioral Disorders in Mucopolysaccharidoses: Transcriptomic Studies

Department of Molecular Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland
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Int. J. Mol. Sci. 2020, 21(3), 1156; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031156
Received: 13 November 2019 / Revised: 31 January 2020 / Accepted: 6 February 2020 / Published: 10 February 2020
(This article belongs to the Special Issue Mucopolysaccharidoses: Diagnosis, Treatment, and Management)
Mucopolysaccharidoses (MPS) are a group of inherited metabolic diseases caused by mutations leading to defective degradation of glycosaminoglycans (GAGs) and their accumulation in cells. Among 11 known types and subtypes of MPS, neuronopathy occurs in seven (MPS I, II, IIIA, IIIB, IIIC, IIID, VII). Brain dysfunctions, occurring in these seven types/subtypes include various behavioral disorders. Intriguingly, behavioral symptoms are significantly different between patients suffering from various MPS types. Molecular base of such differences remains unknown. Here, we asked if expression of genes considered as connected to behavior (based on Gene Ontology, GO terms) is changed in MPS. Using cell lines of all MPS types, we have performed transcriptomic (RNA-seq) studies and assessed expression of genes involved in behavior. We found significant differences between MPS types in this regard, with the most severe changes in MPS IIIA (the type considered as the behaviorally most severely affected), while the lowest changes in MPS IVA and MPS VI (types in which little or no behavioral disorders are known). Intriguingly, relatively severe changes were found also in MPS IVB (in which, despite no behavioral disorder noted, the same gene is mutated as in GM1 gangliosidosis, a severe neurodegenerative disease) and MPS IX (in which only a few patients were described to date, thus, behavioral problems are not well recognized). More detailed analyses of expression of certain genes allowed us to propose an association of specific changes in the levels of transcripts in specific MPS types to certain behavioral disorders observed in patients. Therefore, this work provides a principle for further studies on the molecular mechanism of behavioral changes occurring in MPS patients. View Full-Text
Keywords: mucopolysaccharidosis; transcriptomics; behavioral disorders mucopolysaccharidosis; transcriptomics; behavioral disorders
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MDPI and ACS Style

Pierzynowska, K.; Gaffke, L.; Podlacha, M.; Węgrzyn, G. Genetic Base of Behavioral Disorders in Mucopolysaccharidoses: Transcriptomic Studies. Int. J. Mol. Sci. 2020, 21, 1156. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031156

AMA Style

Pierzynowska K, Gaffke L, Podlacha M, Węgrzyn G. Genetic Base of Behavioral Disorders in Mucopolysaccharidoses: Transcriptomic Studies. International Journal of Molecular Sciences. 2020; 21(3):1156. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031156

Chicago/Turabian Style

Pierzynowska, Karolina, Lidia Gaffke, Magdalena Podlacha, and Grzegorz Węgrzyn. 2020. "Genetic Base of Behavioral Disorders in Mucopolysaccharidoses: Transcriptomic Studies" International Journal of Molecular Sciences 21, no. 3: 1156. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21031156

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