Peer-Review Record
Lung Cancer (LC) in HIV Positive Patients: Pathogenic Features and Implications for Treatment
Int. J. Mol. Sci. 2020, 21(5), 1601; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051601
by
Stefano Frega 1, Alessandra Ferro 1,2, Laura Bonanno 1
, Valentina Guarneri 1,2, PierFranco Conte 1,2 and Giulia Pasello 1,*
, Valentina Guarneri 1,2, PierFranco Conte 1,2 and Giulia Pasello 1,*Reviewer 1:
Anonymous
Reviewer 2:
Int. J. Mol. Sci. 2020, 21(5), 1601; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21051601
Submission received: 12 January 2020
/
Revised: 12 February 2020
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Accepted: 21 February 2020
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Published: 26 February 2020
(This article belongs to the Special Issue Lung Diseases and Infections in the New Era)
Round 1
Reviewer 1 Report
I read with interest your review. I have just few suggestions:
1) modified the FIg.2 is not so clear
2) Table 1 should be improved
Author Response
We analyzed critically the figure 2, previously the message of the figure itself could be misleading for the readers. Thus, we modified the layout of the text, modified the two main titles, modified the title of the figure caption and added a phrase in the figure caption to clarify the strong interplay between HIV immune suppression, the cancer risk and cancer immune-evasion in HIV patients and the application of immune check point inhibitors in this context. Now, the previously named table 1 is named as table 2, because we just added a new table, to respond to other reviewer comment. After your advise, we added new recent available trials about the topic in the table 2, and also added a column with the drug tested (when indicated).Reviewer 2 Report
This is about lung cancer in HIV+ patients. And I understand there are not many data on these patients.
Major Commnets
Please describe the differences concisey between HIV+ and - patients with lung cancer. For example, Demographic differnces in table format; the infulence of curative treatment of lung cancer on HIV, and vice versa, etc.Minor commnets
Line 63, typo There are repeated '1's before many subtitles.Author Response
We added a new table (table 1) with respective caption, to describe the main differences in LC features between HIV infected and HIV uninfected individuals. We modified line 63 sentence that previously did not sound good in english.This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.
