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Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China
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Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Mol. Sci. 2020, 21(7), 2347; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072347
Received: 17 February 2020 / Revised: 17 March 2020 / Accepted: 25 March 2020 / Published: 28 March 2020
(This article belongs to the Special Issue Neuroregeneration and Brain Repair after Stroke)
Background: Cardiac complications after a stroke are the second leading cause of death worldwide, affecting the treatment and outcomes of stroke patients. Cardiac biomarkers such as cardiac troponin (cTn), brain natriuretic peptide (BNP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) have been frequently reported in patients undergoing a stroke. The aim of the present study is to meta-analyze the relationship between changes in such cardiac biomarkers and stroke and to present a systematic review of the previous literature, so as to explore the brain–heart axis. Methods: We searched four online databases pertinent to the literature, including PubMed, Embase, the Cochrane Library, and the Web of Science. Then, we performed a meta-analysis to investigate changes in cTn, BNP, and NT-proBNP associated with different types of stroke. Results and Conclusions: A significant increase in cTnI concentration was found in patients exhibiting a brain hemorrhage. BNP increased in cases of brain infarction, while the NT-proBNP concentration was significantly elevated in patients suffering an acute ischemic stroke and brain hemorrhage, indicating cardiac damage and dysfunction after a stroke. Our analysis suggests that several potential mechanisms may be involved in the brain–heart axis. Finally, clinicians should pay careful attention to monitoring cardiac function in the treatment of cerebrovascular diseases in order to provide a timely and more accurate treatment. View Full-Text
Keywords: brain–heart axis; cardiac troponin; BNP; NT-proBNP; stroke; brain hemorrhage; ischemic stroke; meta-analysis brain–heart axis; cardiac troponin; BNP; NT-proBNP; stroke; brain hemorrhage; ischemic stroke; meta-analysis
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MDPI and ACS Style

Xu, C.; Zheng, A.; He, T.; Cao, Z. Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2020, 21, 2347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072347

AMA Style

Xu C, Zheng A, He T, Cao Z. Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2020; 21(7):2347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072347

Chicago/Turabian Style

Xu, Chengyang, Ang Zheng, Tianyi He, and Zhipeng Cao. 2020. "Brain–Heart Axis and Biomarkers of Cardiac Damage and Dysfunction after Stroke: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 21, no. 7: 2347. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072347

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