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Multifaceted Role of PRDM Proteins in Human Cancer

1
Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 80138 Naples, Italy
2
Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
3
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
4
Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy
5
Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2648; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072648
Received: 12 February 2020 / Revised: 29 March 2020 / Accepted: 8 April 2020 / Published: 10 April 2020
(This article belongs to the Special Issue Zinc-Finger Proteins in Health and Disease: Focus on PRDMs)
The PR/SET domain family (PRDM) comprise a family of genes whose protein products share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1)] homologous domain structurally and functionally similar to the catalytic SET [Su(var)3-9, enhancer-of-zeste and trithorax] domain of histone methyltransferases (HMTs). These genes are involved in epigenetic regulation of gene expression through their intrinsic HMTase activity or via interactions with other chromatin modifying enzymes. In this way they control a broad spectrum of biological processes, including proliferation and differentiation control, cell cycle progression, and maintenance of immune cell homeostasis. In cancer, tumor-specific dysfunctions of PRDM genes alter their expression by genetic and/or epigenetic modifications. A common characteristic of most PRDM genes is to encode for two main molecular variants with or without the PR domain. They are generated by either alternative splicing or alternative use of different promoters and play opposite roles, particularly in cancer where their imbalance can be often observed. In this scenario, PRDM proteins are involved in cancer onset, invasion, and metastasis and their altered expression is related to poor prognosis and clinical outcome. These functions strongly suggest their potential use in cancer management as diagnostic or prognostic tools and as new targets of therapeutic intervention. View Full-Text
Keywords: PRD-BF1 and RIZ homology domain containing gene family; human malignancies; The Cancer Genome Atlas; genetic alterations; prognosis and therapy PRD-BF1 and RIZ homology domain containing gene family; human malignancies; The Cancer Genome Atlas; genetic alterations; prognosis and therapy
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MDPI and ACS Style

Casamassimi, A.; Rienzo, M.; Di Zazzo, E.; Sorrentino, A.; Fiore, D.; Proto, M.C.; Moncharmont, B.; Gazzerro, P.; Bifulco, M.; Abbondanza, C. Multifaceted Role of PRDM Proteins in Human Cancer. Int. J. Mol. Sci. 2020, 21, 2648. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072648

AMA Style

Casamassimi A, Rienzo M, Di Zazzo E, Sorrentino A, Fiore D, Proto MC, Moncharmont B, Gazzerro P, Bifulco M, Abbondanza C. Multifaceted Role of PRDM Proteins in Human Cancer. International Journal of Molecular Sciences. 2020; 21(7):2648. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072648

Chicago/Turabian Style

Casamassimi, Amelia; Rienzo, Monica; Di Zazzo, Erika; Sorrentino, Anna; Fiore, Donatella; Proto, Maria C.; Moncharmont, Bruno; Gazzerro, Patrizia; Bifulco, Maurizio; Abbondanza, Ciro. 2020. "Multifaceted Role of PRDM Proteins in Human Cancer" Int. J. Mol. Sci. 21, no. 7: 2648. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21072648

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