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Review

Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, 580, bloco 17, São Paulo 05508-000, Brazil
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Int. J. Mol. Sci. 2021, 22(1), 469; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010469
Received: 4 November 2020 / Revised: 7 December 2020 / Accepted: 29 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Mitochondrial Calcium Signaling)
Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca2+ pool. Protozoan parasites such as Plasmodium falciparum, Toxoplasma gondii, and Trypanosoma cruzi display a Ca2+ signaling toolkit with similarities to higher eukaryotes, including the participation of mitochondria in Ca2+-dependent signaling events. This review summarizes the most recent knowledge in mitochondrial Ca2+ signaling in protozoan parasites, focusing on the mechanism involved in mitochondrial Ca2+ uptake by pathogenic protists. View Full-Text
Keywords: mitochondria; calcium signaling; protozoan parasites mitochondria; calcium signaling; protozoan parasites
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MDPI and ACS Style

Scarpelli, P.H.; Pecenin, M.F.; Garcia, C.R.S. Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria. Int. J. Mol. Sci. 2021, 22, 469. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010469

AMA Style

Scarpelli PH, Pecenin MF, Garcia CRS. Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria. International Journal of Molecular Sciences. 2021; 22(1):469. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010469

Chicago/Turabian Style

Scarpelli, Pedro H., Mateus F. Pecenin, and Celia R.S. Garcia 2021. "Intracellular Ca2+ Signaling in Protozoan Parasites: An Overview with a Focus on Mitochondria" International Journal of Molecular Sciences 22, no. 1: 469. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22010469

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