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Article

Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish

Department of Life Science, National Taiwan University, Taipei 10617, Taiwan
*
Author to whom correspondence should be addressed.
H.-J. Chuang and C.-Y. Chang contributed equally to this study.
Academic Editor: Joëlle Dupont
Int. J. Mol. Sci. 2021, 22(14), 7459; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147459
Received: 25 May 2021 / Revised: 24 June 2021 / Accepted: 9 July 2021 / Published: 12 July 2021
(This article belongs to the Special Issue Nonapeptide Hormones)
The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors. View Full-Text
Keywords: oxytocin system; oxytocin receptor; zebrafish; stress; environmental stressors; environmental markers oxytocin system; oxytocin receptor; zebrafish; stress; environmental stressors; environmental markers
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MDPI and ACS Style

Chuang, H.-J.; Chang, C.-Y.; Ho, H.-P.; Chou, M.-Y. Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish. Int. J. Mol. Sci. 2021, 22, 7459. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147459

AMA Style

Chuang H-J, Chang C-Y, Ho H-P, Chou M-Y. Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish. International Journal of Molecular Sciences. 2021; 22(14):7459. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147459

Chicago/Turabian Style

Chuang, Hsin-Ju, Chun-Yung Chang, Huai-Ping Ho, and Ming-Yi Chou. 2021. "Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish" International Journal of Molecular Sciences 22, no. 14: 7459. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147459

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