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Review

Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia

1
Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche, Universita’ di Padova, 35122 Padova, Italy
2
UOC Immunologia e Diagnostica Molecolare Oncologica, Istituto Oncologico Veneto IOV—IRCCS, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Mahmoud Huleihel
Int. J. Mol. Sci. 2021, 22(16), 8738; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168738
Received: 19 July 2021 / Revised: 4 August 2021 / Accepted: 11 August 2021 / Published: 14 August 2021
(This article belongs to the Special Issue Metabolism and Leukemia: From Biology to Therapies)
Acute leukemias, classified as acute myeloid leukemia and acute lymphoblastic leukemia, represent the most prevalent hematologic tumors in adolescent and young adults. In recent years, new challenges have emerged in order to improve the clinical effectiveness of therapies already in use and reduce their side effects. In particular, in this scenario, metabolic reprogramming plays a key role in tumorigenesis and prognosis, and it contributes to the treatment outcome of acute leukemia. This review summarizes the latest findings regarding the most relevant metabolic pathways contributing to the continuous growth, redox homeostasis, and drug resistance of leukemia cells. We describe the main metabolic deregulations in acute leukemia and evidence vulnerabilities that could be exploited for targeted therapy. View Full-Text
Keywords: acute leukemia; targeted therapy; metabolism acute leukemia; targeted therapy; metabolism
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MDPI and ACS Style

Di Martino, L.; Tosello, V.; Peroni, E.; Piovan, E. Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia. Int. J. Mol. Sci. 2021, 22, 8738. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168738

AMA Style

Di Martino L, Tosello V, Peroni E, Piovan E. Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia. International Journal of Molecular Sciences. 2021; 22(16):8738. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168738

Chicago/Turabian Style

Di Martino, Ludovica, Valeria Tosello, Edoardo Peroni, and Erich Piovan. 2021. "Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia" International Journal of Molecular Sciences 22, no. 16: 8738. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168738

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