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Review

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

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Department of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
2
Department of Anatomy and Embriology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
3
Department of Plastic and Reconstructive Surgery, Life Memorial Hospital, 365 Grivitei Street, 010719 Bucharest, Romania
4
Department of Family Medicine and Clinical Base, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Aleksandra Klimczak
Int. J. Mol. Sci. 2021, 22(17), 9512; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179512
Received: 31 July 2021 / Revised: 26 August 2021 / Accepted: 30 August 2021 / Published: 1 September 2021
(This article belongs to the Special Issue Molecular and Biochemical Aspects in Burns)
Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries. View Full-Text
Keywords: burns; growth factors; reactive oxygen species; metformin; wound healing; signaling pathways burns; growth factors; reactive oxygen species; metformin; wound healing; signaling pathways
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MDPI and ACS Style

Miricescu, D.; Badoiu, S.C.; Stanescu-Spinu, I.-I.; Totan, A.R.; Stefani, C.; Greabu, M. Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns? Int. J. Mol. Sci. 2021, 22, 9512. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179512

AMA Style

Miricescu D, Badoiu SC, Stanescu-Spinu I-I, Totan AR, Stefani C, Greabu M. Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns? International Journal of Molecular Sciences. 2021; 22(17):9512. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179512

Chicago/Turabian Style

Miricescu, Daniela, Silviu C. Badoiu, Iulia-Ioana Stanescu-Spinu, Alexandra R. Totan, Constantin Stefani, and Maria Greabu. 2021. "Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?" International Journal of Molecular Sciences 22, no. 17: 9512. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179512

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