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The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

1
Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy
2
Istituto Oncologico Veneto, IOV-IRCCS, 35128 Padua, Italy
3
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2021, 22(2), 974; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020974
Received: 30 December 2020 / Revised: 15 January 2021 / Accepted: 16 January 2021 / Published: 19 January 2021
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as “cytokine storm”. View Full-Text
Keywords: SARS-CoV-2; COVID19; pathology; cytokine storm SARS-CoV-2; COVID19; pathology; cytokine storm
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MDPI and ACS Style

Zarrilli, G.; Angerilli, V.; Businello, G.; Sbaraglia, M.; Traverso, G.; Fortarezza, F.; Rizzo, S.; De Gaspari, M.; Basso, C.; Calabrese, F.; Dei Tos, A.P.; Fassan, M. The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury. Int. J. Mol. Sci. 2021, 22, 974. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020974

AMA Style

Zarrilli G, Angerilli V, Businello G, Sbaraglia M, Traverso G, Fortarezza F, Rizzo S, De Gaspari M, Basso C, Calabrese F, Dei Tos AP, Fassan M. The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury. International Journal of Molecular Sciences. 2021; 22(2):974. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020974

Chicago/Turabian Style

Zarrilli, Giovanni, Valentina Angerilli, Gianluca Businello, Marta Sbaraglia, Giulia Traverso, Francesco Fortarezza, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Fiorella Calabrese, Angelo P. Dei Tos, and Matteo Fassan. 2021. "The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury" International Journal of Molecular Sciences 22, no. 2: 974. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22020974

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