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Review

Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?

1
INMED, INSERM, Aix-Marseille University, 13007 Marseille, France
2
CNRS, ISM, Aix-Marseille University, 13007 Marseille, France
*
Author to whom correspondence should be addressed.
Academic Editor: Yuji Ueno
Int. J. Mol. Sci. 2021, 22(6), 3003; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063003
Received: 8 February 2021 / Revised: 10 March 2021 / Accepted: 11 March 2021 / Published: 16 March 2021
(This article belongs to the Special Issue Neuroregeneration and Brain Repair after Stroke)
Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limitations related to the clinical relevance of studies on the exercise recommendations in individuals with stroke are first discussed. Then, the relevance of HIIT in improving neurotrophic factors expression, neurogenesis and synaptic plasticity is debated in both stroke and healthy individuals (humans and rodents). Moreover, HIIT may have a preventive role on stroke severity, as found in rodents. The potential role of HIIT in stroke rehabilitation is reinforced by findings showing its powerful neurogenic effect that might potentiate cognitive benefits induced by cognitive tasks. In addition, the clinical role of neuroplasticity observed in each hemisphere needs to be clarified by coupling more frequently to cellular/molecular measurements and behavioral testing. View Full-Text
Keywords: stroke rehabilitation; cerebral ischemia; cognition; endurance exercise; neurotrophic factors; neurogenesis; angiogenesis; rat and human model stroke rehabilitation; cerebral ischemia; cognition; endurance exercise; neurotrophic factors; neurogenesis; angiogenesis; rat and human model
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MDPI and ACS Style

Hugues, N.; Pellegrino, C.; Rivera, C.; Berton, E.; Pin-Barre, C.; Laurin, J. Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? Int. J. Mol. Sci. 2021, 22, 3003. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063003

AMA Style

Hugues N, Pellegrino C, Rivera C, Berton E, Pin-Barre C, Laurin J. Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke? International Journal of Molecular Sciences. 2021; 22(6):3003. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063003

Chicago/Turabian Style

Hugues, Nicolas, Christophe Pellegrino, Claudio Rivera, Eric Berton, Caroline Pin-Barre, and Jérôme Laurin. 2021. "Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?" International Journal of Molecular Sciences 22, no. 6: 3003. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063003

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