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Review

ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

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Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia
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Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
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Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia
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Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar
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Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha P.O. Box 2713, Qatar
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V.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, Russia
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Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation 8/2 Trubenskaya Street, 119991 Moscow, Russia
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Federal Research Centre for Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Passage, 109240 Moscow, Russia
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Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Academic Editor: Godfrey Getz
Int. J. Mol. Sci. 2021, 22(9), 4691; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094691
Received: 28 March 2021 / Revised: 17 April 2021 / Accepted: 27 April 2021 / Published: 29 April 2021
COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis. View Full-Text
Keywords: COVID-19; coronavirus disease; atherosclerosis; ACE2 COVID-19; coronavirus disease; atherosclerosis; ACE2
MDPI and ACS Style

Poznyak, A.V.; Bezsonov, E.E.; Eid, A.H.; Popkova, T.V.; Nedosugova, L.V.; Starodubova, A.V.; Orekhov, A.N. ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis. Int. J. Mol. Sci. 2021, 22, 4691. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094691

AMA Style

Poznyak AV, Bezsonov EE, Eid AH, Popkova TV, Nedosugova LV, Starodubova AV, Orekhov AN. ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis. International Journal of Molecular Sciences. 2021; 22(9):4691. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094691

Chicago/Turabian Style

Poznyak, Anastasia V., Evgeny E. Bezsonov, Ali H. Eid, Tatyana V. Popkova, Ludmila V. Nedosugova, Antonina V. Starodubova, and Alexander N. Orekhov 2021. "ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis" International Journal of Molecular Sciences 22, no. 9: 4691. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094691

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