Int. J. Mol. Sci., Volume 22, Issue 9 (May-1 2021) – 760 articles
Cover Story (view full-size image): The EBI2 receptor regulates chemotaxis of immune cells and is involved in autoimmune diseases such as multiple sclerosis. Specifically, in the central nervous system, it is expressed in astrocytes where it regulates chemotaxis and neuroinflammatory response. Here, the expression and function of EBI2 in oligodendrocytes were demonstrated in the human brain and MO3.13 oligodendrocytes. The data showed EBI2 in oligodendrocyte progenitor cells in the human brain, temporal upregulation during MO3.13 maturation, as well as induction of chemotaxis. Antagonism of EBI2 inhibited spontaneous remyelination in organotypic cerebellar slices. These data provide alternative approaches to the regulation of oligodendrocyte biology and potential new therapeutic opportunities for demyelination diseases. View this paper
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