Topical Collection "Carbonic Anhydrase and Carbonic Anhydrase Inhibitors"
Interests: drug design; metalloenzymes; carbonic anhydrases, anticancer agents; antiinfectives; sulfonamides; coumarins
Special Issues and Collections in MDPI journals
Special Issue in Metabolites: Cancer Metabolomics 2016
Special Issue in Pathogens: Pathogen Legionella pneumophila
Special Issue in International Journal of Molecular Sciences: Enzyme-Inhibitor Interaction as Examples of Molecular Recognition
Special Issue in Molecules: Sulfonamides
Special Issue in Metabolites: Carbonic Anhydrases and Metabolism
Special Issue in Marine Drugs: Carbonic Anhydrase in Marine Organism
Special Issue in Molecules: Metalloenzyme Inhibitors and Activators
Special Issue in International Journal of Molecular Sciences: Protease and Carbonic Anhydrase Inhibitors and Their Roles in Pathological Processes
Special Issue in Metabolites: Carbonic Anhydrases and Metabolism Volume 2
Topical Collection in International Journal of Molecular Sciences: 21st Anniversary of IJMS: Advances in Biochemistry
Special Issue in International Journal of Molecular Sciences: Protease and Carbonic Anhydrase Inhibitors, II
Special Issue in International Journal of Molecular Sciences: Biochemistry, Molecular Biology and Druggability of Proteins
Special Issue in Metabolites: Metabolism in the Tumor Microenvironment
Special Issue in International Journal of Molecular Sciences: ECMS2021: Druggable Targets of Emerging Infectious Diseases
Special Issue in International Journal of Molecular Sciences: Tackling New and Reemerging Infectious Diseases through the Development of Novel Anti-infectives
Special Issue in Molecules: Feature Reviews in Bioorganic Chemistry
The metalloenzyme carbonic anhydrase (CA) is expressed in organisms all over the phylogenetic tree of life, with eight genetic families known to date. By equilibrating CO2 and bicarbonate with the generation of protons, CAs play a crucial role in pH regulation, electrolyte secretion, metabolism (lipogenesis, gluconeogenesis, ureagenesis). CA inhibitors are clinically used as diuretics, antiglaucoma agents, and antiepileptics, but novel applications in the management of cancer, neuropathic pain, sleep apnea, migraine, intracranial pressure lowering, and cerebral ischemia are being investigated. CA activators are involved in memory and fear extinction, and are thus useful in the treatment of cognitive impairment and phobias. This topical collection provides an update in these fields, with reviews/original articles dedicated to the various applications of inhibitors/activators in therapy as well as biomedical applications of prokaryotic CAs, with CAs widely abundant in pathogenic bacteria in addition to fungi, protozoa, and other pathogens. The modulators of activity of these enzymes offer useful applications in a variety of biomedical and biotechnological fields.
Prof. Dr. Claudiu T. Supuran
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- Carbonic anhydrase
- Antitumor agent
- Alzheimer’s disease