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Review

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

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Department of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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Edinburgh Molecular Imaging Ltd. (EMI), Edinburgh EH16 4UX, UK
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Department of Radiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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Biomedical Photonic Imaging Group, University of Twente, 7500 AE Enschede, The Netherlands
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Department of Cell & Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
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Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA
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Percuros B.V., 2333 CL Leiden, The Netherlands
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Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Hideyuki Yamawaki
Int. J. Mol. Sci. 2021, 22(9), 4804; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094804
Received: 9 April 2021 / Revised: 27 April 2021 / Accepted: 28 April 2021 / Published: 30 April 2021
(This article belongs to the Special Issue Endoglin in Health and Disease)
Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the progress in endoglin-based imaging of cancer, atherosclerosis, myocardial infarction, and aortic aneurysm, focusing on positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), near-infrared fluorescence (NIRF) imaging, and ultrasound imaging. PubMed was searched combining the following subjects and their respective synonyms or relevant subterms: “Endoglin”, “Imaging/Image-guided surgery”. In total, 59 papers were found eligible to be included: 58 reporting about preclinical animal or in vitro models and one ex vivo study in human organs. In addition to exact data extraction of imaging modality type, tumor or cardiovascular disease model, and tracer (class), outcomes were described via a narrative synthesis. Collectively, the data identify endoglin as a suitable target for intraoperative and diagnostic imaging of the neovasculature in tumors, whereas for cardiovascular diseases, the evidence remains scarce but promising. View Full-Text
Keywords: endoglin; CD105; TGF-β; imaging; image-guided surgery; molecular imaging; nanoparticles; microbubbles; angiogenesis; cancer; cardiovascular diseases endoglin; CD105; TGF-β; imaging; image-guided surgery; molecular imaging; nanoparticles; microbubbles; angiogenesis; cancer; cardiovascular diseases
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MDPI and ACS Style

Sier, V.Q.; van der Vorst, J.R.; Quax, P.H.A.; de Vries, M.R.; Zonoobi, E.; Vahrmeijer, A.L.; Dekkers, I.A.; de Geus-Oei, L.-F.; Smits, A.M.; Cai, W.; Sier, C.F.M.; Goumans, M.J.T.H.; Hawinkels, L.J.A.C. Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review. Int. J. Mol. Sci. 2021, 22, 4804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094804

AMA Style

Sier VQ, van der Vorst JR, Quax PHA, de Vries MR, Zonoobi E, Vahrmeijer AL, Dekkers IA, de Geus-Oei L-F, Smits AM, Cai W, Sier CFM, Goumans MJTH, Hawinkels LJAC. Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review. International Journal of Molecular Sciences. 2021; 22(9):4804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094804

Chicago/Turabian Style

Sier, Vincent Q.; van der Vorst, Joost R.; Quax, Paul H.A.; de Vries, Margreet R.; Zonoobi, Elham; Vahrmeijer, Alexander L.; Dekkers, Ilona A.; de Geus-Oei, Lioe-Fee; Smits, Anke M.; Cai, Weibo; Sier, Cornelis F.M.; Goumans, Marie J.T.H.; Hawinkels, Lukas J.A.C. 2021. "Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review" Int. J. Mol. Sci. 22, no. 9: 4804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094804

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