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Article

Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data

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Department of Oral & Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
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Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea
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Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Dongtan 18450, Korea
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Department of Biomedical Sciences, College of Medicine, Hallym University, Chuncheon 24252, Korea
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Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
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Department of Otorhinolaryngology-Head & Neck Surgery, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
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Department of Otorhinolaryngology-Head & Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Dongtan 18450, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(14), 5237; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17145237
Received: 18 June 2020 / Revised: 16 July 2020 / Accepted: 16 July 2020 / Published: 20 July 2020
(This article belongs to the Special Issue Oral Pathologies and Their Impact on Public Health)
This cross-sectional study aimed to evaluate the association between periodontitis and cardiovascular disease (CVD) by reviewing and discussing the role of the oral microbiome in periodontitis and CVD. This prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study from 2004 to 2016. We selected 9973 patients with periodontitis and 125,304 controls (non-periodontitis) from 173,209 participants and analyzed their medical histories to determine the relationship between cerebral stroke/ischemic heart disease and periodontitis. The participants were questioned about any previous history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke (hemorrhagic or ischemic), ischemic heart disease (angina or myocardial infarction), and periodontitis. Their body mass index, smoking habit, alcohol intake, nutritional intake, and income were recorded. The Chi-square test, independent t-test, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of periodontitis for stroke was 1.35 (95% confidence interval (CI) = 1.16–1.57, p < 0.001). The aOR of periodontitis for ischemic heart disease was 1.34 (95% CI = 1.22–1.48, p < 0.001). We concluded that periodontitis was associated with CVD and may be a risk factor for CVD. However, further studies are required to determine the association between periodontal treatment and CVD. View Full-Text
Keywords: periodontal diseases; risk factor; periodontitis; cardiovascular disease; stroke; ischemic heart disease; inflammation; oral health periodontal diseases; risk factor; periodontitis; cardiovascular disease; stroke; ischemic heart disease; inflammation; oral health
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MDPI and ACS Style

Byun, S.H.; Lee, S.; Kang, S.H.; Choi, H.G.; Hong, S.J. Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data. Int. J. Environ. Res. Public Health 2020, 17, 5237. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17145237

AMA Style

Byun SH, Lee S, Kang SH, Choi HG, Hong SJ. Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data. International Journal of Environmental Research and Public Health. 2020; 17(14):5237. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17145237

Chicago/Turabian Style

Byun, Soo H., Sunki Lee, Sung H. Kang, Hyo G. Choi, and Seok J. Hong 2020. "Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data" International Journal of Environmental Research and Public Health 17, no. 14: 5237. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17145237

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