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Cytomegalovirus Infection and Inflammation in Developing Brain

1
Center for Proteomics and Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
2
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Stamminger
Received: 19 May 2021 / Revised: 1 June 2021 / Accepted: 3 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue State-of-the-Art Virology Research in Croatia)
Human cytomegalovirus (HCMV) is a highly prevalent herpesvirus that can cause severe disease in immunocompromised individuals and immunologically immature fetuses and newborns. Most infected newborns are able to resolve the infection without developing sequelae. However, in severe cases, congenital HCMV infection can result in life-threatening pathologies and permanent damage of organ systems that possess a low regenerative capacity. Despite the severity of the problem, HCMV infection of the central nervous system (CNS) remains inadequately characterized to date. Cytomegaloviruses (CMVs) show strict species specificity, limiting the use of HCMV in experimental animals. Infection following intraperitoneal administration of mouse cytomegalovirus (MCMV) into newborn mice efficiently recapitulates many aspects of congenital HCMV infection in CNS. Upon entering the CNS, CMV targets all resident brain cells, consequently leading to the development of widespread histopathology and inflammation. Effector functions from both resident cells and infiltrating immune cells efficiently resolve acute MCMV infection in the CNS. However, host-mediated inflammatory factors can also mediate the development of immunopathologies during CMV infection of the brain. Here, we provide an overview of the cytomegalovirus infection in the brain, local immune response to infection, and mechanisms leading to CNS sequelae. View Full-Text
Keywords: cytomegalovirus; congenital HCMV infection; mouse cytomegalovirus; inflammation; latency; central nervous system; CMV tropism; immune response cytomegalovirus; congenital HCMV infection; mouse cytomegalovirus; inflammation; latency; central nervous system; CMV tropism; immune response
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MDPI and ACS Style

Krstanović, F.; Britt, W.J.; Jonjić, S.; Brizić, I. Cytomegalovirus Infection and Inflammation in Developing Brain. Viruses 2021, 13, 1078. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061078

AMA Style

Krstanović F, Britt WJ, Jonjić S, Brizić I. Cytomegalovirus Infection and Inflammation in Developing Brain. Viruses. 2021; 13(6):1078. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061078

Chicago/Turabian Style

Krstanović, Fran, William J. Britt, Stipan Jonjić, and Ilija Brizić. 2021. "Cytomegalovirus Infection and Inflammation in Developing Brain" Viruses 13, no. 6: 1078. https://0-doi-org.brum.beds.ac.uk/10.3390/v13061078

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