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Article

First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications

1
Medical Faculty, Lazarski University, 02-662 Warsaw, Poland
2
Division of Gynecological Surgery, University Hospital, 33 Polna Str., 60-535 Poznan, Poland
3
Department of Computer Science and Statistics, Poznan University of Medical Sciences, 60-806 Poznan, Poland
4
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, 71-252 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Received: 28 March 2020 / Revised: 10 April 2020 / Accepted: 13 April 2020 / Published: 16 April 2020
(This article belongs to the Special Issue Dietary Minerals and Human Health)
Microelements involved in the oxidative balance have a significant impact on human health, but their role in pregnancy are poorly studied. We examined the relationships between first trimester levels of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu), as well as maternal characteristics and pregnancy results. The data came from a Polish prospective cohort of women in a single pregnancy without chronic diseases. A group of 563 women who had a complete set of data, including serum microelements in the 10–14th week was examined, and the following were found: 47 deliveries <37th week; 48 cases of birth weight <10th and 64 newborns >90th percentile; 13 intrauterine growth restriction (IUGR) cases; 105 gestational hypertension (GH) and 15 preeclampsia (PE) cases; and 110 gestational diabetes mellitus (GDM) cases. The microelements were quantified using mass spectrometry. The average concentrations (and ranges) of the elements were as follows: Se: 60.75 µg/L (40.91–125.54); Zn: 618.50 µg/L (394.04–3238.90); Cu: 1735.91 µg/L (883.61–3956.76); and Fe: 1018.33 µg/L (217.55–2806.24). In the multivariate logistic regression, we found that an increase in Se of 1 µg/L reduces the risk of GH by 6% (AOR = 0.94; p = 0.004), the risk of IUGR by 11% (AOR = 0.89; p = 0.013), and the risk of birth <34th week by 7% (but close to the significance) (AOR = 0.93; p = 0.061). An increase in Fe of 100 µg/L reduces the risk of PE by 27% (AOR = 0.73; p = 0.009). In the multivariable linear regression, we found negative strong associations between prepregnancy BMI, Se (β = −0.130; p = 0.002), and Fe (β = −0.164; p < 0.0001), but positive associations with Cu (β = 0.320; p < 0.000001). The relationships between Se and maternal age (β = 0.167; p < 0.0001), Se and smoking (β = −0.106; p = 0.011) and Cu, and gestational age from the 10–14th week (β = 0.142; p < 0.001) were also found. Secondary education was associated with Zn (β = 0.132; p = 0.004) and higher education was associated with Cu (β = −0.102; p = 0.023). A higher financial status was associated with Fe (β = 0.195; p = 0.005). Other relationships were statistically insignificant. Further research is needed to clarify relationships between first trimester microelements and pregnancy complications. In addition, attention should be paid to lifestyle-related and socioeconomic factors that affect microelement levels. View Full-Text
Keywords: selenium; antioxidants; microelements; pregnancy; determinants; risk selenium; antioxidants; microelements; pregnancy; determinants; risk
MDPI and ACS Style

Lewandowska, M.; Więckowska, B.; Sajdak, S.; Lubiński, J. First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications. Nutrients 2020, 12, 1108. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12041108

AMA Style

Lewandowska M, Więckowska B, Sajdak S, Lubiński J. First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications. Nutrients. 2020; 12(4):1108. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12041108

Chicago/Turabian Style

Lewandowska, Małgorzata, Barbara Więckowska, Stefan Sajdak, and Jan Lubiński. 2020. "First Trimester Microelements and Their Relationships with Pregnancy Outcomes and Complications" Nutrients 12, no. 4: 1108. https://0-doi-org.brum.beds.ac.uk/10.3390/nu12041108

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