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Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy
Article

Implications of SCFAs on the Parameters of the Lipid and Hepatic Profile in Pregnant Women

1
Department of Perinatology, Obstetrics and Gynecology Pomeranian Medical University in Szczecin, 2 Siedlecka Str., 72-010 Police, Poland
2
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 24 Broniewskiego Str., 71-460 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Beatriz Merino
Received: 25 April 2021 / Revised: 20 May 2021 / Accepted: 20 May 2021 / Published: 21 May 2021
(This article belongs to the Special Issue Fat Diets and Metabolic Diseases)
Short-chain fatty acids (SCFAs) are the product of the anaerobic intestinal bacterial fermentation of dietary fiber and resistant starch. An abnormal intestinal microbiota may cause a reduction in the production of SCFAs, which stimulate the development of intestinal epithelial cells, nourish enterocytes, influence their maturation and proper differentiation, reduce the pH, and are an additional source of energy for the host. There have been reports of the special role of SCFAs in the regulation of glucose and lipid metabolism during pregnancy. Aim: The aim of the study was to analyze the correlation of SCFAs with lipid and hepatic metabolism during pregnancy in relation to the body weight of pregnant women. Material and methods: This study was conducted in pregnant women divided into two groups: Obese (OW—overweight and obese women; n = 48) and lean (CG—control group; n = 48) individuals. The biochemical plasma parameters of lipid metabolism (TG, CH, LDL, HDL), inflammation (CRP), and liver function (ALT, AST, GGT) were determined in all of the subjects. SCFA analysis was performed in the stool samples to measure acetic acid (C 2:0), propionic acid (C 3:0), isobutyric acid (C 4:0 i), butyric acid (C 4:0 n), isovaleric acid (C 5:0 i) valeric acid (C 5:0 n), isocaproic acid (C 6:0 i), caproic acid (C 6:0 n), and heptanoic acid (C 7:0). Results: Statistically significant differences in the concentrations of C 3:0 and C 6:0 n were found between women in the OW group compared to the CG group. The other SCFAs tested did not differ significantly depending on BMI. The C 2:0, C 3:0, and C 4:0 n ratios showed differences in both OW and CG groups. In the OW group, no relationship was observed between the concentrations of the SCFAs tested and CRP, ALT, AST. A surprising positive relationship between C 5:0 n and all fractions of the tested lipids and branched C 5:0 with CHL, HDL, and LDL was demonstrated. In the OW group, HDL showed a positive correlation with C 3:0. However, lower GGT concentrations were accompanied by higher C 4:0 and C 5:0 values, and this tendency was statistically significant. Conclusions: The results of our research show that some SCFAs are associated with hepatic lipid metabolism and CRP concentrations, which may vary with gestational weight. Obesity in pregnancy reduces the amount of SCFAs in the stool, and a decrease in the level of butyrate reduces liver function. View Full-Text
Keywords: SCFAs; pregnancy; propionic acid; butyric acid; caproic acid; heptanoic acid; valeric acid SCFAs; pregnancy; propionic acid; butyric acid; caproic acid; heptanoic acid; valeric acid
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MDPI and ACS Style

Ziętek, M.; Celewicz, Z.; Kikut, J.; Szczuko, M. Implications of SCFAs on the Parameters of the Lipid and Hepatic Profile in Pregnant Women. Nutrients 2021, 13, 1749. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13061749

AMA Style

Ziętek M, Celewicz Z, Kikut J, Szczuko M. Implications of SCFAs on the Parameters of the Lipid and Hepatic Profile in Pregnant Women. Nutrients. 2021; 13(6):1749. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13061749

Chicago/Turabian Style

Ziętek, Maciej, Zbigniew Celewicz, Justyna Kikut, and Małgorzata Szczuko. 2021. "Implications of SCFAs on the Parameters of the Lipid and Hepatic Profile in Pregnant Women" Nutrients 13, no. 6: 1749. https://0-doi-org.brum.beds.ac.uk/10.3390/nu13061749

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