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Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson’s Disease: An Updated Review
Article

Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease

1
Institute of Anatomy, Rostock University Medical Center, D-18057 Rostock, Germany
2
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Macroscopic and Clinical Anatomy, Medical University of Graz, A-8010 Graz, Austria
3
Institute of Medical Genetics, Rostock University Medical Center, D-18057 Rostock, Germany
4
Centre of Transdisciplinary Neuroscience Rostock, D-18147 Rostock, Germany
*
Author to whom correspondence should be addressed.
Received: 17 June 2021 / Revised: 9 July 2021 / Accepted: 14 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue Botulinum Neurotoxin and Parkinson’s Disease)
Parkinson’s patients often suffer from depression and anxiety, for which there are no optimal treatments. Hemiparkinsonian (hemi-PD) rats were used to test whether intrastriatal Botulinum neurotoxin-A (BoNT-A) application could also have antidepressant-like properties in addition to the known improvement of motor performance. To quantify depression- and anxiety-like behavior, the forced swim test, tail suspension test, open field test, and elevated plus maze test were applied to hemi-PD rats injected with BoNT-A or vehicle. Furthermore, we correlated the results in the forced swim test, open field test, and elevated plus maze test with the rotational behavior induced by apomorphine and amphetamine. Hemi-PD rats did not show significant anxiety-like behavior as compared with Sham 6-OHDA- + Sham BoNT-A-injected as well as with non-injected rats. However, hemi-PD rats demonstrated increased depression-like behaviors compared with Sham- or non-injected rats; this was seen by increased struggling frequency and increased immobility frequency. Hemi-PD rats intrastriatally injected with BoNT-A exhibited reduced depression-like behavior compared with the respective vehicle-receiving hemi-PD animals. The significant effects of intrastriatally applied BoNT-A seen in the forced swim test are reminiscent of those found after various antidepressant drug therapies. Our data correspond with the efficacy of BoNT-A treatment of glabellar frown lines in treating patients with major depression and suggest that also intrastriatal injected BoNT-A may have some antidepressant-like effect on hemi-PD. View Full-Text
Keywords: hemiparkinsonian rat; 6-OHDA; botulinum neurotoxin-A; depression; striatum; behavior; forced swim test; tail suspension test; open field test; elevated plus maze test; correlation analysis hemiparkinsonian rat; 6-OHDA; botulinum neurotoxin-A; depression; striatum; behavior; forced swim test; tail suspension test; open field test; elevated plus maze test; correlation analysis
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MDPI and ACS Style

Antipova, V.; Holzmann, C.; Hawlitschka, A.; Witt, M.; Wree, A. Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Toxins 2021, 13, 505. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13070505

AMA Style

Antipova V, Holzmann C, Hawlitschka A, Witt M, Wree A. Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease. Toxins. 2021; 13(7):505. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13070505

Chicago/Turabian Style

Antipova, Veronica, Carsten Holzmann, Alexander Hawlitschka, Martin Witt, and Andreas Wree. 2021. "Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson’s Disease" Toxins 13, no. 7: 505. https://0-doi-org.brum.beds.ac.uk/10.3390/toxins13070505

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