Quantitative Optical Coherence Tomography for Longitudinal Monitoring of Postnatal Retinal Development in Developing Mouse Eyes
Round 1
Reviewer 1 Report
I just have a minor comment:
How a mice model results can be extended to human data?
The data presented herein are in vivo, I was wondering have authors performed any study on human?
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
It is not mentioned in the title that this study was conducted on animals (mice), this fact should be mentioned, without this it s misleading.
What was the basis for choosing P14, P17, P21, P28, P56? Why these particular postnatal days and these periods of time are important? In the abstract postnatal days should also be mentioned. First 56 postnatal days in mice have been analysed.
Could you be more specific in regard to C57BL/6 mice? In what experiments are they usually used?
In the abstract it has been written as follows: „A better study of the postnatal retinal development is not only essential for the in-depth understanding of the nature of the vision system but also may provide insights for treatment developments of eye conditions, such as retinopathy of premature (ROP).” This sentence should not be used at the beginning of the abstract, it is rather conclusion than the introduction. In the manuscript I have not found any mention about retinopathy of prematurity.
The phrase „retinopathy of prematurity” should be used instead of „retinopathy of premature”.
In regard to the discussion, are there any studies on the brain development in mice in the first postnatal days? Retina is a part of central nervous system, thus the discussion may be extended.
Only studies in mice are discussed in the discussion chapter, are there any studien in humans in regard to OCT of the retina in the first postnatal days?
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
All comments have been adressed properly.
Author Response
Thank you!
