Next Article in Journal
The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus
Next Article in Special Issue
Antimicrobial Resistance Patterns and Antibiotic Use during Hospital Conversion in the COVID-19 Pandemic
Previous Article in Journal
Drivers of Broad-Spectrum Antibiotic Overuse across Diverse Hospital Contexts—A Qualitative Study of Prescribers in the UK, Sri Lanka and South Africa
Previous Article in Special Issue
OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance
Open AccessArticle

Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards

1
Department of Biomedical Sciences and Public Health, Section of Hygiene, Preventive Medicine and Public Health, Università Politecnica delle Marche, 60126 Ancona, Italy
2
Geriatrics, Santa Croce Hospital, Azienda Ospedaliera Ospedali Riuniti Marche Nord, 61032 Fano, Italy
3
Geriatria, Accettazione Geriatrica e Centro di Ricerca Per L’invecchiamento, IRCCS INRCA, 60124 Ancona, Italy
*
Author to whom correspondence should be addressed.
Received: 11 December 2020 / Revised: 14 January 2021 / Accepted: 16 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Antibiotics Use and Antimicrobial Resistance in Hospital)
The impact of the COVID-19 pandemic on multidrug-resistant (MDR) bacteria is unknown. The purpose of this study was to assess prevalence, etiology, and association with mortality of MDR bacteria in older adult patients before and after the first peak of the COVID-19 pandemic in Italy. An observational retrospective study was conducted in two geriatric wards of the Azienda Ospedaliera Ospedali Riuniti Marche Nord, Fano, and of the INRCA, IRCCS, Ancona, in the Marche Region, Italy, from December 2019 to February 2020 and from May to July 2020. A total of 73 patients (mean age 87.4 ± 5.9, 27.4% men) and 83 cultures (36 pre-COVID-19 and 47 post-COVID-19) were considered. Overall, 46 cultures (55.4%) reported MDR bacteria (50% in pre- and 59.6% in post-COVID-19 period, p = 0.384). MDR bacteria in bloodstream significantly increased in post-COVID-19 period (68.8% vs. 40.0% p = 0.038) and MDR bacteria in urine did not change (51.6 vs. 54.8%, p = 0.799). Escherichia coli was the main MDR bacterium in pre-COVID-19, p = 0.082 and post-COVID-19, p = 0.026. Among patients with MDR infection, in-hospital mortality was 37.5% and 68.8% in pre- and post-COVID-19, respectively (p = 0.104), and mortality at 30 days was higher in post-COVID-19 period (78.9% vs. 27.3%, p = 0.012). An increased number of MDR bacteria in bloodstream and mortality after MDR infection have been observed in the post-COVID-19 period. View Full-Text
Keywords: multidrug-resistant bacteria; COVID-19; Staphylococcus; older adults; hospitalization multidrug-resistant bacteria; COVID-19; Staphylococcus; older adults; hospitalization
Show Figures

Figure 1

MDPI and ACS Style

Gasperini, B.; Cherubini, A.; Lucarelli, M.; Espinosa, E.; Prospero, E. Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards. Antibiotics 2021, 10, 95. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010095

AMA Style

Gasperini B, Cherubini A, Lucarelli M, Espinosa E, Prospero E. Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards. Antibiotics. 2021; 10(1):95. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010095

Chicago/Turabian Style

Gasperini, Beatrice; Cherubini, Antonio; Lucarelli, Moira; Espinosa, Emma; Prospero, Emilia. 2021. "Multidrug-Resistant Bacterial Infections in Geriatric Hospitalized Patients before and after the COVID-19 Outbreak: Results from a Retrospective Observational Study in Two Geriatric Wards" Antibiotics 10, no. 1: 95. https://0-doi-org.brum.beds.ac.uk/10.3390/antibiotics10010095

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop