Compartment Model of Mixing in a Bubble Trap and Its Impact on Chromatographic Separations
Round 1
Reviewer 1 Report
The manuscript entitled: 'Compartment model of mixing in a bubble trap and its impact on chromatographic separations' is written and presented in an excellent way. There is no comments.
Author Response
We have corrected several typing errors.
Reviewer 2 Report
General comment: The aim of this work is interesting, i.e. to model mixing behaviour of a bubble trap with a compartment model in order to explain and predict related band-broadening effects. Moreover, used English is satisfactory, but several typing errors are present, so I please the authors to correct them. Furthermore, there are some minor issues I suggest the author to consider:
- I think the sentence in lines L102-104 is a comment actually. I suggest the authors to remove it;
- In Table 1, I suggest the authors to separate different runs for a single NaCl concentration with continuous lines to avoid misunderstanding and to help readers to relate runs with the relative salt concentration;
- In L187, only the mean value of CSTR2 is reported. The coefficient of variation of the parameter could be inserted here too to appreciate the entity of variation of this parameter among different density levels.
I suggest the authors to review the article in order to correct different typing errors present in the paper too. Here there are some examples:
L12: selected instead of select
L15: showed instead of show
L30: is smaller than instead of is small in relation to
L54: a instead of an
L58: straightforward instead of straight forward
L164: 2mL, respectively instead of 2mL. respectively
Author Response
- I think the sentence in lines L102-104 is a comment actually. I suggest the authors to remove it;
A: We have removed this sentence.
- In Table 1, I suggest the authors to separate different runs for a single NaCl concentration with continuous lines to avoid misunderstanding and to help readers to relate runs with the relative salt concentration;
A: Has been corrected as suggested by the reviewer.
- In L187, only the mean value of CSTR2 is reported. The coefficient of variation of the parameter could be inserted here too to appreciate the entity of variation of this parameter among different density levels.
A: Coefficient of variation has been inserted.
I suggest the authors to review the article in order to correct different typing errors present in the paper too. Here there are some examples:
L12: selected instead of select
L15: showed instead of show
L30: is smaller than instead of is small in relation to
L54: a instead of an
L58: straightforward instead of straight forward
L164: 2mL, respectively instead of 2mL. respectively
A: Typing errors have been corrected accordingly.
Reviewer 3 Report
The present study introduces a compartment model of mixing in a bubble trap and assesses its impact on a chromatographic separation. The work is very interesting, and it is well organized and reported. Therefore, some minor aspects should be taken into account:
- 1-A comparison with previous approaches based on CFD (state of the art) would be valuable to highlight the novelty of the work.
- A more complete overview about the impact and future perspectives of this work should also be added to the manuscript.
- In section 2.4, room temperature should be defined.
Author Response
- 1-A comparison with previous approaches based on CFD (state of the art) would be valuable to highlight the novelty of the work.
A: We agree, a comparison with CFD simulation would be interesting. To our knowledge mixing in a bubble trap of this kind has not been simulated by CFD. However, we think thatit is out of scope for this particular work to perform CFD simulation. Coupling of CFD with full mechanistic chromatography models is not trivial. In fact, our itention was to generate a simple model which can easily be built into currently avaialble chromatographymodelling software. By doing so, we think we can help many users of such software packages to straightly apply our model to this and similar mixing problems.
- A more complete overview about the impact and future perspectives of this work should also be added to the manuscript.
A: We have added potential future application in the discussion section.
- In section 2.4, room temperature should be defined.
A: Room temperature has been defined and added.
