Insecticide Resistance Development and the Underlying Mechanisms

Dear Colleagues,

The evolution of insecticide resistance represents a global constraint to agricultural production. Understanding the molecular basis of insecticide resistance and designing efficient insecticide resistance management strategies (IRM) are of paramount importance. It is recognized that insect resistance to insecticides is developed principally through two mechanisms, either the target insensitivity mechanism caused by gene mutations or the metabolic resistance mechanism through changes in the quantity and quality of detoxification enzyme genes. The metabolic resistance mechanism is responsible for the development of cross-resistance to a wide range of insecticides. In addition, multiple resistance mechanisms are commonly observed in resistant insects; however, their relative contribution to the phenotype remains elusive and their interactive effects on insecticide resistance development are under studied. Moreover, the impact of ecological factors, such as climate warming, plant viruses or insect bacterial symbiosis, on insecticide resistance evolution is less understood. Here, we are gathering both original research and review papers on the following research topics:

• Resistance development and basic nature of insecticide resistance;
• Candidate genes and genome alterations associated with the phenotype identified by high-throughput comparative transcriptomic, proteomic and/or genomic approaches;
• Mutations in coding gene(s) or cis and/or trans mutations involved in resistance;
• Functional validation of the candidate genes or mutations by in vitro and in vivo methods;
• Interactive effects of two or multiple mechanisms on insecticide resistance development;
• Fitness cost of insecticide resistance and suggestions on resistance management strategies;
• The impact of ecological factors, such as climate warming, plant viruses or insect bacterial symbiosis, on insecticide resistance development;
• Design of molecular diagnostics to monitor insecticide resistance in the field;
• Products or methods of pest management and resistance management.

Dr. Youhui Gong
Dr. Xin Yang
Guest Editor

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• insecticide resistance development and evolution
• resistance mechanism
• target insensitivity mechanism
• metabolic resistance mechanism
• detoxification enzyme genes
• overexpression
• gene mutation
• phenotype
• resistance contribution
• ecological factors