Dear Colleagues,

Metabolic syndrome is a collection of cardiometabolic risk factors that include obesity, insulin-resistance, hypertension, and dyslipidemia. This condition is often associated with an increased risk of developing diabetes and cardiovascular disease, and it is also characterized by increased oxidative stress and chronic inflammatory processes.

In recent decades, the use of natural compounds for the treatment and prevention of metabolic disorders has attracted the general attention of the scientific community because of their potential biological efficacy and low or no side effects.

However, the bioactivity of many natural compounds is closely related to their bioaccessibility through the gastrointestinal tract and consequently their bioavailability through the systemic circulation to the target tissues where they can exert their biological effects. The bioavailability of many compounds is generally low, and the metabolic pathways, as well as the mechanisms of action responsible for their biological activities, are often still unknown. In addition, other factors appear to further influence the bioactivity of natural compounds, such as the qualitative and quantitative composition of the matrix in which they occur (in terms of synergism and/or antagonism effects), their structure, and the metabolic processes mediated by the gut, microbiota and liver.

In this Special Issue, we invite researchers to submit original research articles or review papers addressing the potential effect of bioaccessible and bioavailable bioactive molecules, occurring in the food matrixes, on metabolic syndrome and its related disorders. We are pleased to invite research papers dealing with studies on in vitro or in vivo models and clinical trials with the main objective of expanding knowledge in this field and gaining new insights.

Prof. Dr. José Ángel Rufián-Henares
Dr. Fortuna Iannuzzo
Dr. Maria Maisto
Dr. Elisabetta Schiano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• natural bioactive compound
• oxidative stress
• inflammation
• metabolic syndrome
• bioaccessibility
• bioavailability
• metabolization
• food matrix