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Antioxidants
Special Issues
Natural Antioxidants and Metabolic Diseases
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Natural Antioxidants and Metabolic Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 1534

Special Issue Editors

Prof. Dr. José Ángel Rufián-Henares

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Guest Editor
Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Granada, Campus de Cartuja S/N, 18012 Granada, Spain
Interests: antioxidant capacity; personalized nutrition; gut microbiota; chemical browning; diet
Special Issues, Collections and Topics in MDPI journals
Dr. Fortuna Iannuzzo

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutraceuticals; polyphenols; food chemistry; chromatography; mass spectrometry; food science
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Maisto

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutraceuticals; bioactive compounds; antioxidant activity; mass spectrometry; chromatography
Special Issues, Collections and Topics in MDPI journals
Dr. Elisabetta Schiano

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Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutrition; metabolic diseases; nutraceuticals; polyphenols; in vitro enzymatic assays; cell line culture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases such as diabetes, obesity, dyslipidemia, hypertension, and cardiovascular diseases present major challenges to global health; thus, the investigation of natural antioxidant compounds offers a promising perspective. These compounds, which are derived from food and vegetables sources, have demonstrated a range of biological effects, positioning themselves as potential therapeutic and preventive agents.

This Special Issue is dedicated to examining natural antioxidant compounds and their impact on metabolic diseases. The role of these molecules extends well beyond their basic nutritional function; they can significantly influence cellular processes, reduce oxidative stress, and modulate the inflammatory and metabolic responses of the body.

We invite researchers in the fields of food chemistry, nutrition, biochemistry, pharmacology, and the medical sciences to submit original research articles, clinical reports, and review articles. Your participation and contributions are crucial to enriching the body of knowledge and gaining new insights in this field. With this Special Issue, we aim to provide a comprehensive and up-to-date overview of the advancement and potential of these compounds in supporting health and the management of metabolic diseases.

Prof. Dr. José Ángel Rufián-Henares
Dr. Fortuna Iannuzzo
Dr. Maria Maisto
Dr. Elisabetta Schiano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • antioxidant compounds
  • diabetes
  • obesity
  • cardiovascular diseases
  • biological effects
  • food sources
  • medicinal plants
  • oxidative stress
  • inflammation

Published Papers (2 papers)

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Research

16 pages, 3190 KiB  
Article
Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism
by Ziming Yang, Li Zhang, Jinlei Liu and Dianpeng Li
Antioxidants 2024, 13(4), 495; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13040495 - 21 Apr 2024
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Abstract
Litchi pericarp is rich in polyphenols, and demonstrates significant biological activity. This study assessed the therapeutic effects of litchi pericarp extract (LPE) on type 2 diabetes mellitus in db/db mice. The results showed that LPE ameliorated symptoms of glucose metabolism disorder, oxidative stress, [...] Read more.
Litchi pericarp is rich in polyphenols, and demonstrates significant biological activity. This study assessed the therapeutic effects of litchi pericarp extract (LPE) on type 2 diabetes mellitus in db/db mice. The results showed that LPE ameliorated symptoms of glucose metabolism disorder, oxidative stress, inflammatory response, and insulin resistance in db/db mice. The mechanistic studies indicated that LPE activates adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) and suppresses the protein expression of phosphoenolpyruvate carboxykinase (PEPCK), thereby reducing hepatic gluconeogenesis. Additionally, LPE facilitates the translocation of nuclear factor erythroid2-related factor 2 (Nrf2) into the cell nucleus, initiating the transcription of antioxidant factors superoxide dismutase (SOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1), which alleviate oxidative stress and reduce oxidative damage. Furthermore, LPE blocks nuclear factor kappa-B (NF-κB) nuclear translocation and subsequent inflammatory response initiation, thereby reducing inflammation. These findings indicate that LPE addresses type 2 diabetes mellitus by activating the AMPK energy metabolic pathway and regulating the Nrf2 oxidative stress and NF-κB inflammatory signaling pathways. Full article
(This article belongs to the Special Issue Natural Antioxidants and Metabolic Diseases)
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15 pages, 5214 KiB  
Article
Syrah Grape Polyphenol Extracts Protect Human Skeletal Muscle Cells from Oxidative and Metabolic Stress Induced by Excess of Palmitic Acid: Effect of Skin/Seed Ripening Stage
by Adriana Capozzi, Auriane Dudoit, Luca Garcia, Gilles Carnac, Gérald Hugon, Cédric Saucier, Catherine Bisbal and Karen Lambert
Antioxidants 2024, 13(3), 373; https://0-doi-org.brum.beds.ac.uk/10.3390/antiox13030373 - 19 Mar 2024
Viewed by 809
Abstract
Metabolic skeletal muscle (SM) dysfunction, triggered by increased oxidative stress and mitochondrial impairment, is a pivotal contributor to obesity-associated insulin resistance (IR). Addressing obesity and SM IR demands substantial lifestyle changes including regular exercise and dietary adjustments that are difficult to follow over [...] Read more.
Metabolic skeletal muscle (SM) dysfunction, triggered by increased oxidative stress and mitochondrial impairment, is a pivotal contributor to obesity-associated insulin resistance (IR). Addressing obesity and SM IR demands substantial lifestyle changes including regular exercise and dietary adjustments that are difficult to follow over time. This prompted exploration of alternative approaches. Grape polyphenols (GPPs) have demonstrated a positive impact on metabolism, although few studies have focused on SM. Since grape polyphenolic content and composition depend on tissue and ripening, we explored the antioxidant potential of GPPs from skin (Sk) and seeds (Sd) extracted before veraison (Bv) and at mature (M) stages, on palmitate-induced IR in primary human SM cells. Despite their important difference in polyphenol (PP) content: Sd-BvPP > Sd-MPP/Sk-BvPP > Sk-MPP, all extracts reduced lipid peroxidation by 44–60%, up-regulated the heme-oxygenase 1 protein level by 75–132% and mitochondrial activity by 47–68%. Contrary to the other extracts, which improved insulin response by 50%, Sd-BvPP did not. Our findings suggest that compounds other than stilbenoids or anthocyanin-type molecules, present only in grape Sk, could play an active role in regulating SM oxidative and metabolic stress and insulin sensitivity, paving the way for further exploration of novel bioactive compounds. Full article
(This article belongs to the Special Issue Natural Antioxidants and Metabolic Diseases)
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