ROS and COVID-19 II
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 15399
Special Issue Editor
Interests: antioxidant activity; plant phenolics; exercise; functional foods; toxicology; redox nutrition; antioxidant administration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Coronavirus Disease 2019 (COVID-19) is caused by a novel coronavirus, SARS-CoV-2. While in many cases the disease is mild, severe COVID-19 involves a hyper-inflammatory response, commonly called a cytokine storm, which is characterized by the release of pro-inflammatory cytokines that can lead to Acute Respiratory Distress Syndrome and death. The pulmonary immunity in elderly persons is known to be compromised, with impaired innate and adaptive cellular immune responses and reduced function of the lung itself. While overall innate immune responses may decline with age, inflammatory cytokines such as IL-6 and TNF-a, and acute phase reactants such as C-reactive protein, are elevated in the elderly, maintaining a low level of chronic inflammation. This is associated with increased levels of oxidative stress which drive the sustained levels of inflammation.
Risk factors for severe COVID-19, such as obesity and diabetes, are also associated with oxidative stress. Viral entry into the cytoplasm of the host cells results in interactions that affect cell metabolism and induce oxidative stress responses. For this reason, many aspects of ROS study (nutrition modalities, supplements administration, redox biomarker study, antioxidant involvement, drug–protein interaction, vaccines, physiology, and/or biochemistry of ROS in COVID-19) are of particular interest and are the focus of the present Special Issue.
Prof. Dr. Dimitrios Kouretas
Guest Editor
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