Dear Colleagues,

The approach of using redox biomarkers in the evaluation of the antioxidant profile both in vitro and in vivo has recently resurfaced. Although usually overlooked, recent scientific evidence indicates that redox biomarkers can become a useful tool with great translational potency in the field of redox biology. As defined by Veskoukis et al. in 2019 (10.1016/j.cotox.2018.10.001), a redox biomarker might be an antioxidant molecule modified following interaction with reactive species, the products of the detrimental impact of reactive species on biomolecules, and the reactive species per se. Furthermore, terms such as “oxidant” and “pro-oxidant” seem rather vague today as they have not been fully elucidated. On the same basis, the characterization of a compound as “antioxidant” is not sufficient since this term does not denote exactly the biological role of a given substance. Indeed, it is not clear whether the molecule in question prevents oxidation of biomolecules or repairs the oxidative modifications they have already undergone. To this end, redox biomarkers can putatively offer a valuable service in this area since, when functionally clustered, they might give the appropriate information for the actual role of an antioxidant.

In this Special Issue, we invite researchers to contribute both review papers and original research articles that will approach the issue of using biomarkers in order to evaluate, on one hand, the antioxidant status of nutritional agents in vitro and, on the other hand. the redox status of a wide range of organisms in vivo. Potential topics include but are not limited to the following:

• Biomarkers used for the evaluation of in vivo antioxidant mechanisms;
• Biomarkers for assessing the antioxidant activity of plant compounds in vitro;
• Antioxidant status in disease versus health using redox biomarkers;
• Evaluation of redox status in aging.

Prof. Dr. Dimitrios Kouretas
Dr. Fotios Tekos
Guest Editors

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• antioxidants
• redox biomarkers
• redox biology