Applied Sciences

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Prof. Dr. Cornelis Hans Pameijer

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Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA
Interests: biomaterials; endodontics; bioactivity; vital pulp capping; histology; prosthodontics

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Dear Colleagues,

Until recently, people believed that dental materials must be inert in order to be successful. Bioactive materials stimulate cells to produce bone tissues, secondary dentin or are active in the surface precipitation of calcium phosphates or hydroxyapatite. They can stimulate healing and cause the remineralization of hard tissues. Examples of bone regeneration can be found in orthopedics, implant dentistry and periodontics, such as ridge augmentation. Pulp capping materials with bioactivity have demonstrated that they promote bridge formation after vital pulp exposure, and in endodontics, applications have been reported in root resorption cases, the obturation of the root canal space and periapical healing. In restorative dentistry, a favorable soft tissue response, the remineralization of hard tissues and the occlusion of the marginal gap are some of the advantages that have been reported. Furthermore, a favorable postoperative reaction after the cementation of fixed prosthesis has been reported. This issue invites manuscripts that cover, but are not limited, to the above presented applications.

Prof. Dr. Cornelis Hans Pameijer
Guest Editor

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Keywords

bioactivity
restorative dentistry
remineralization
periodontics
endodontics
bone formation

Published Papers (1 paper)

Research

11 pages, 4939 KiB

Open AccessArticle

Tissue Response to a Heat Resistant Silicate-Based and an Epoxy Resin-Based Endodontic Sealer Implanted in Rat Tibias

by Osvaldo Zmener, Cornelis H. Pameijer, Roberto Della Porta and Romina de Lucca

Appl. Sci. 2023, 13(18), 10075; https://0-doi-org.brum.beds.ac.uk/10.3390/app131810075 - 07 Sep 2023

Viewed by 776

Abstract

Introduction: The effect of high temperatures on the properties of endodontic sealers during warm compaction of gutta-percha may be a matter of concern. This study aimed to evaluate the effect of heat on the biocompatibility and bioactivity of EndoSequence BC Sealer HiFlow (ESHF; Brasseler, Savannah, GA, USA) and AH Plus (AHPS; Dentsply, De Trey, Konstanz, Germany) when implanted into the bone tissue of rat tibias. Methods: Medical-grade silicone tubes containing freshly prepared ESHF or AHPS were heated to 100 °C and then cooled down to 65 °C before being implanted in the tibias of 24 Wistar rats. The outer walls of the tubes served as controls. After 10, 30 and 90 days, the animals were euthanized and the implants and their surrounding tissues were dissected, fixed in formalin, and processed for microscopic evaluation. Results: After 10 days postoperatively, a severe inflammatory reaction without reactionary bone formation was observed in contact with ESHF and AHPS. The severity of the reaction had decreased at the 30-day observation period for both sealers but only ESHF samples showed new bone formation adjacent to the sealer. After 90 days, no inflammatory cells were found in contact with ESHF, while a thin fibrous tissue capsule and complete bone reparation of the surrounding areas were observed in contact with the material. For AH Plus, a fibrous connective tissue containing scarce remaining inflammatory cells could be observed in most of the samples, however, in the absence of new bone formation. No significant differences (p > 0.05) between ESHF and AHPS were found at the 10-day observation period. At the 30 and 90-day, significant differences (p < 0.05) between both materials were observed. The reaction to the controls showed significant differences with ESHF and AHPS for all experimental periods. Significant differences (p < 0.05) for the total effect of time were also found between both sealers (p < 0.05). Conclusions: At the end of the experiment, heated ESHF reacted as a biocompatible/bioactive material and stimulated continued development of new healthy bone. Although AHPS was tolerated well by the surrounding tissues, the sealer did not promote new reparative bone formation. Full article

(This article belongs to the Special Issue Bioactive Dental Materials: A Paradigm Shift in Dentistry?)

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