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Applied Sciences
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Nanotechnology in Tissue Engineering
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Nanotechnology in Tissue Engineering

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 13021

Special Issue Editors

Dr. Anna Calarco

E-Mail Website
Guest Editor
Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino, 80131 Naples, Italy
Interests: nanotechnology; biomaterials; analytical methodologies applied to the chemical composition evaluation and nutritional property determination of natural substances; HPLC and UHPLC; GC; photodiode array detection (PDA); mass spectrometry (MS)
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Di Salle

E-Mail Website
Guest Editor
Research Institute on Terrestrial Ecosystems (IRET) - CNR, Via Pietro Castellino, 111, 80131 Naples, Italy
Interests: HPLC; bacteria–material interaction; tissue regeneration; biomaterials
Dr. Raffaele Conte

E-Mail Website
Guest Editor
Toxicology and clinical chemistry laboratory of “AMES polydiagnostic centre”, Via Padre Carmine Fico 24, 80013 Casalnuovo di Napoli (NA) Italy
Interests: nanomaterial synthesis and characterization; tissue regeneration; cell toxicology

Special Issue Information

Dear Colleagues,

This Special Issue highlights the current state and future prospects of nanomaterials applied in the tissue engineering (TE) field. TE represents the most promising technology for regenerating damaged tissues and organs, integrating principles and methods of engineering, material science, and medical biology. Due to their unique properties, nanomaterials such as nanofibers, nanotubes, nanoparticles, and other nanofabricated devices are able to mimic the complex hierarchical structure of the native tissue, contributing to tissue regeneration. This topic includes articles and reviews focused on the fabrication, characterization, and application of bio-nanomaterials based on organic and inorganic nanostructures and different natural or synthetic biopolymers. Research articles on biomaterial surface technology, cell–biomaterial interaction, and nanobiomaterial properties will also be included in this Issue.

Dr. Anna Calarco
Dr. Anna Di Salle
Dr. Raffaele Conte
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regeneration
  • nanomaterials
  • cell–material interactions
  • cell differentiation
  • bacteria–material interactions

Published Papers (2 papers)

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Review

16 pages, 2971 KiB  
Review
Bioactivity and Delivery Strategies of Phytochemical Compounds in Bone Tissue Regeneration
by Anna Valentino, Francesca Di Cristo, Michela Bosetti, Amal Amaghnouje, Dalila Bousta, Raffaele Conte and Anna Calarco
Appl. Sci. 2021, 11(11), 5122; https://0-doi-org.brum.beds.ac.uk/10.3390/app11115122 - 31 May 2021
Cited by 13 | Viewed by 3311
Abstract
Plant-derived secondary metabolites represent a reservoir of phytochemicals for regenerative medicine application because of their varied assortment of biological properties including anti-oxidant, anti-inflammatory, antibacterial, and tissue remodeling properties. In addition, bioactive phytochemicals can be easily available, are often more cost-effective in large-scale industrialization, [...] Read more.
Plant-derived secondary metabolites represent a reservoir of phytochemicals for regenerative medicine application because of their varied assortment of biological properties including anti-oxidant, anti-inflammatory, antibacterial, and tissue remodeling properties. In addition, bioactive phytochemicals can be easily available, are often more cost-effective in large-scale industrialization, and can be better tolerated compared to conventional treatments mitigating the long-lasting side effects of synthetic compounds. Unfortunately, their poor bioavailability and lack of long-term stability limit their clinical impact. Nanotechnology-based delivery systems can overcome these limitations increasing bioactive molecules’ local effectiveness with reduction of the possible side effects on healthy bone. This review explores new and promising strategies in the area of delivery systems with particular emphasis on solutions that enhance bioavailability and/or health effects of plant-derived phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and curcumin in bone tissue regeneration. Full article
(This article belongs to the Special Issue Nanotechnology in Tissue Engineering)
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19 pages, 1423 KiB  
Review
Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review
by Ilenia De Luca, Parisa Pedram, Arash Moeini, Pierfrancesco Cerruti, Gianfranco Peluso, Anna Di Salle and Natalie Germann
Appl. Sci. 2021, 11(4), 1713; https://0-doi-org.brum.beds.ac.uk/10.3390/app11041713 - 14 Feb 2021
Cited by 47 | Viewed by 9023
Abstract
Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology [...] Read more.
Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings. Full article
(This article belongs to the Special Issue Nanotechnology in Tissue Engineering)
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