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Applied Sciences
Special Issues
Cartilage Regeneration in Osteoarthritis
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Cartilage Regeneration in Osteoarthritis

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 1863

Special Issue Editor

Prof. Dr. Ming Pei

E-Mail Website
Guest Editor
Human Performance - Exercise Physiology, West Virginia University, Morgantown, WV 26506, USA
Interests: cartilage; bone; intervertebral disc and meniscus tissue engineering and regeneration; adult stem cell proliferation and differentiation; decellularized stem cell matrix and reconstruction of an in vitro 3D microenvironment; chondrogenic; osteogenic; adipogenic signaling pathways and epigenetic regulation

Special Issue Information

Dear Colleagues,

As the most common form of arthritis, osteoarthritis affects millions of people worldwide, often resulting from injury or obesity in middle age. Cartilage injury triggers osteoarthritis, and osteoarthritis prevents injured cartilage from regeneration. This Special Issue aims to provide a showcase of the current achievements in the investigation of the molecular mechanisms underlying osteoarthritis and of the biological treatment of cartilage defects in a harsh osteoarthritic environment. Topics may include, but are not limited to, pharmacological treatment and cell therapy, as well as genetic approach. Research articles, review articles, and short communications are all welcome!

Prof. Dr. Ming Pei
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • cartilage regeneration
  • inflammation
  • cartilage defect
  • stem cell
  • tissue engineering

Published Papers (1 paper)

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Research

17 pages, 8048 KiB  
Article
Hypoxia Modulates Regenerative Potential of Fetal Stem Cells
by Yixuan Amy Pei and Ming Pei
Appl. Sci. 2022, 12(1), 363; https://0-doi-org.brum.beds.ac.uk/10.3390/app12010363 - 30 Dec 2021
Cited by 1 | Viewed by 1398
Abstract
Adult mesenchymal stem cells (MSCs) are prone to senescence, which limits the scope of their use in tissue engineering and regeneration and increases the likelihood of post-implantation failure. As a robust alternative cell source, fetal stem cells can prevent an immune reaction and [...] Read more.
Adult mesenchymal stem cells (MSCs) are prone to senescence, which limits the scope of their use in tissue engineering and regeneration and increases the likelihood of post-implantation failure. As a robust alternative cell source, fetal stem cells can prevent an immune reaction and senescence. However, few studies use this cell type. In this study, we sought to characterize fetal cells’ regenerative potential in hypoxic conditions. Specifically, we examined whether hypoxic exposure during the expansion and differentiation phases would affect human fetal nucleus pulposus cell (NPC) and fetal synovium-derived stem cell (SDSC) plasticity and three-lineage differentiation potential. We concluded that fetal NPCs represent the most promising cell source for chondrogenic differentiation, as they are more responsive and display stronger phenotypic stability, particularly when expanded and differentiated in hypoxic conditions. Fetal SDSCs have less potential for chondrogenic differentiation compared to their adult counterpart. This study also indicated that fetal SDSCs exhibit a discrepancy in adipogenic and osteogenic differentiation in response to hypoxia. Full article
(This article belongs to the Special Issue Cartilage Regeneration in Osteoarthritis)
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