Dear Colleagues,

[¹⁸F]FDG was the first and main radiopharmaceutical for positron emission tomography (PET) imaging for many decades, used for imaging and measuring increased glucose metabolism in tumor cells. In the footsteps of [¹⁸F]FDG, many other first-generation radiopharmaceuticals obtained the MA, mainly used for tumor localization and staging. More recently, facing the growing need for in vivo molecular characterization as companion tools for targeted therapies as well as the new boom of the theranostic approach, PET radiopharmaceuticals have been increasingly developed as a tool for not only imaging tumors or other disease processes but also elucidating various complex biological mechanisms of tumors and metabolic and neurogenerative diseases. To allow the development of these next generation radiopharmaceuticals, new strategies have been developed. In this special issue we will discuss various new PET radiopharmaceuticals, ranging from molecular targeting strategies, pharmacokinetics optimization, development of convenient radiosynthesis, in vitro and in vivo characterization, up to their clinical applications in diagnosis.

Prof. Dr. Peter Laverman
Prof. Dr. Benjamin Guillet
Prof. Dr. Stefano Fanti
Guest Editors

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• Radiopharmaceuticals
• PET
• Imaging
• Radiochemistry