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Advanced Electrochemical Biosensors
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Advanced Electrochemical Biosensors

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 21435

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editor

Prof. Dr. Tae Hyun Kim

E-Mail Website
Guest Editor
Department of Chemistry, Soonchunhyang University, Asan 31538, Korea
Interests: electrochemical sensors; carbon nanomaterials; nanobiosensors; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Electrochemical sensors possess various advantages over conventional sensors, such as high sensitivity and selectivity, simple instrumentation, portability, outstanding compatibility, short analysis time, and low cost. Thus, various types of sensors based on electrochemical techniques have been developed for the detection of chemically, biologically, and environmentally important analytes. With recent developments in advanced material science and electronic technology such as signal processing and front-end electronic systems, electrochemical sensing methods are comprising a very wide range of analytical possibilities. Among these, electrochemical biosensors have attracted significant interest for the detection of biochemical compounds such as biological proteins, nucleotides, and even tissues due to their practical applications in health care, early diagnosis, and environmental monitoring.

Thus, this Special Issue serves the need to promote exploratory research and development on emerging electrochemical biosensor technologies while aiming to present the latest technological and methodological developments in this interdisciplinary field. We invite contributions on topics that include but not limited to various state-of-the-art electrochemical biosensing technologies.

Prof. Dr. Tae Hyun Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • integrated biosensors
  • lab-on-a-chip
  • immunosensors
  • aptasensors
  • advanced sensing platforms
  • nanomaterials
  • medical diagnostics
  • environmental monitoring

Published Papers (6 papers)

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Editorial

Jump to: Research, Review

3 pages, 417 KiB  
Editorial
Toward Emerging Innovations in Electrochemical Biosensing Technology
by Tae Hyun Kim
Appl. Sci. 2021, 11(6), 2461; https://0-doi-org.brum.beds.ac.uk/10.3390/app11062461 - 10 Mar 2021
Cited by 2 | Viewed by 1483
Abstract
With the progress of nanoscience and biotechnology, advanced electrochemical biosensors have been widely investigated for various application fields. Such electrochemical sensors are well suited to miniaturization and integration for portable devices and parallel processing chips. Therefore, advanced electrochemical biosensors can open a new [...] Read more.
With the progress of nanoscience and biotechnology, advanced electrochemical biosensors have been widely investigated for various application fields. Such electrochemical sensors are well suited to miniaturization and integration for portable devices and parallel processing chips. Therefore, advanced electrochemical biosensors can open a new era in health care, drug discovery, and environmental monitoring. This Special Issue serves the need to promote exploratory research and development on emerging electrochemical biosensor technologies while aiming to reflect on the current state of research in this emerging field. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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Research

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13 pages, 3455 KiB  
Article
Self-Assembled MoS2/ssDNA Nanostructures for the Capacitive Aptasensing of Acetamiprid Insecticide
by Maroua Hamami, Noureddine Raouafi and Hafsa Korri-Youssoufi
Appl. Sci. 2021, 11(4), 1382; https://0-doi-org.brum.beds.ac.uk/10.3390/app11041382 - 3 Feb 2021
Cited by 13 | Viewed by 2259
Abstract
The aim of this work is to detect acetamiprid using electrochemical capacitance spectroscopy, which is widely used as a pesticide in agriculture and is harmful to humans. We have designed aptasensing platform based on the adsorption of a DNA aptamer on lipoic acid-modified [...] Read more.
The aim of this work is to detect acetamiprid using electrochemical capacitance spectroscopy, which is widely used as a pesticide in agriculture and is harmful to humans. We have designed aptasensing platform based on the adsorption of a DNA aptamer on lipoic acid-modified MoS2 nano-sheets. The biosensor takes advantage of the high affinity of single-stranded DNA sequences to MoS2 nano-sheets. The stability of DNA on MoS2 nano-sheets is assured by covalent attachment to lipoic acid that forms self-assembled layer on MoS2 surface. The biosensor exhibits excellent capacitance performances owing to its large effective surface area making it interesting material for capacitive transduction system. The impedance-derived capacitance varies with the increasing concentrations of acetamiprid that can be attributed to the aptamer desorption from the MoS2 nanosheets facilitating ion diffusion into MoS2 interlayers. The developed device showed high analytical performances for acetamiprid detection on electrochemical impedance spectroscopy EIS- derived capacitance variation and high selectivity toward the target in presence of other pesticides. Real sample analysis of food stuff such as tomatoes is demonstrated which open the way to their use for monitoring of food contaminants by tailoring the aptamer. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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16 pages, 358 KiB  
Article
A Microfluidic Approach for Biosensing DNA within Forensics
by Brigitte Bruijns, Roald Tiggelaar and Han Gardeniers
Appl. Sci. 2020, 10(20), 7067; https://0-doi-org.brum.beds.ac.uk/10.3390/app10207067 - 12 Oct 2020
Cited by 12 | Viewed by 3344
Abstract
Reducing the risk of (cross-)contamination, improving the chain of custody, providing fast analysis times and options of direct analysis at crime scenes: these requirements within forensic DNA analysis can be met upon using microfluidic devices. To become generally applied in forensics, the most [...] Read more.
Reducing the risk of (cross-)contamination, improving the chain of custody, providing fast analysis times and options of direct analysis at crime scenes: these requirements within forensic DNA analysis can be met upon using microfluidic devices. To become generally applied in forensics, the most important requirements for microfluidic devices are: analysis time, method of DNA detection and biocompatibility of used materials. In this work an overview is provided about biosensing of DNA, by DNA profiling via standard short tandem repeat (STR) analysis or by next generation sequencing. The material of which a forensic microfluidic device is made is crucial: it should for example not inhibit DNA amplification and its thermal conductivity and optical transparency should be suitable for achieving fast analysis. The characteristics of three materials frequently used materials, i.e., glass, silicon and PDMS, are given, in addition to a promising alternative, viz. cyclic olefin copolymer (COC). New experimental findings are presented about the biocompatibility of COC and the use of COC chips for multiple displacement amplification and real-time monitoring of DNA amplification. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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15 pages, 2235 KiB  
Article
Tonic and Phasic Amperometric Monitoring of Dopamine Using Microelectrode Arrays in Rat Striatum
by Martin Lundblad, David A. Price, Jason J. Burmeister, Jorge E. Quintero, Peter Huettl, Francois Pomerleau, Nancy R. Zahniser and Greg A. Gerhardt
Appl. Sci. 2020, 10(18), 6449; https://0-doi-org.brum.beds.ac.uk/10.3390/app10186449 - 16 Sep 2020
Cited by 5 | Viewed by 2603
Abstract
Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous system (CNS) and in [...] Read more.
Here we report a novel microelectrode array recording approach to measure tonic (resting) and phasic release of dopamine (DA) in DA-rich areas such as the rat striatum and nucleus accumbens. The resulting method is tested in intact central nervous system (CNS) and in animals with extensive loss of the DA pathway using the neurotoxin, 6-hydroxyDA (6-OHDA). The self-referencing amperometric recording method employs Nafion-coated with and without m-phenylenediamine recording sites that through real-time subtraction allow for simultaneous measures of tonic DA levels and transient changes due to depolarization and amphetamine-induced release. The recording method achieves low-level measures of both tonic and phasic DA with decreased recording drift allowing for enhanced sensitivity normally not achieved with electrochemical sensors in vivo. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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Review

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14 pages, 383 KiB  
Review
Electrochemical (Bio)Sensing of Maple Syrup Urine Disease Biomarkers Pointing to Early Diagnosis: A Review
by Sophia Karastogianni and Stella Girousi
Appl. Sci. 2020, 10(20), 7023; https://0-doi-org.brum.beds.ac.uk/10.3390/app10207023 - 9 Oct 2020
Cited by 7 | Viewed by 3032
Abstract
Metabolic errors are inherited diseases, where genetic defects prevent a metabolic path, ending up in enzyme malfunction. In correspondence to its remaining or plenitude fall of enzymatic potency, there is an amassment of dangerous metabolites near the metabolic bar and/or a dearth of [...] Read more.
Metabolic errors are inherited diseases, where genetic defects prevent a metabolic path, ending up in enzyme malfunction. In correspondence to its remaining or plenitude fall of enzymatic potency, there is an amassment of dangerous metabolites near the metabolic bar and/or a dearth of necessary products, inducing a certain disease. These metabolic errors may include deviations such as point mutations, expunctions or interferences, or further complicated genomic disorders. Based on these facts, maple syrup urine disease (MSUD) is a scarce metabolic disease, generated by huge concentrations of branched-chain amino acids (b AAs), i.e., leucine, isoleucine, and valine. In this situation, these large amounts of b AAs provoke abnormalities such as liver failure, neurocognitive dysfunctions, and probably death. To overpass those problems, it is crucial to implement a timely and agile diagnosis at the early stages of life in view of their immutable consequence on neonates. Thus, this review will describe MSUD and b AAs analysis based on electrochemical (bio)sensing. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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24 pages, 2848 KiB  
Review
Electrochemical Biosensors Based on Conducting Polymers: A Review
by Boris Lakard
Appl. Sci. 2020, 10(18), 6614; https://0-doi-org.brum.beds.ac.uk/10.3390/app10186614 - 22 Sep 2020
Cited by 99 | Viewed by 8151
Abstract
Conducting polymers are an important class of functional materials that has been widely applied to fabricate electrochemical biosensors, because of their interesting and tunable chemical, electrical, and structural properties. Conducting polymers can also be designed through chemical grafting of functional groups, nanostructured, or [...] Read more.
Conducting polymers are an important class of functional materials that has been widely applied to fabricate electrochemical biosensors, because of their interesting and tunable chemical, electrical, and structural properties. Conducting polymers can also be designed through chemical grafting of functional groups, nanostructured, or associated with other functional materials such as nanoparticles to provide tremendous improvements in sensitivity, selectivity, stability and reproducibility of the biosensor’s response to a variety of bioanalytes. Such biosensors are expected to play a growing and significant role in delivering the diagnostic information and therapy monitoring since they have advantages including their low cost and low detection limit. Therefore, this article starts with the description of electroanalytical methods (potentiometry, amperometry, conductometry, voltammetry, impedometry) used in electrochemical biosensors, and continues with a review of the recent advances in the application of conducting polymers in the recognition of bioanalytes leading to the development of enzyme based biosensors, immunosensors, DNA biosensors, and whole-cell biosensors. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors)
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