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Biomedicines
Special Issues
Hepatotoxicity: From Pathology to Novel Therapeutic Approaches
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Hepatotoxicity: From Pathology to Novel Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 3852

Special Issue Editor

Dr. Sanda Win

E-Mail Website
Guest Editor
Division of Gastrointestinal and Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, 2011 Zonal Ave., HMR 612, Los Angeles, CA 90089, USA
Interests: signal transduction in drug-induced hepatotoxicity; regulation of mitochondrial bioenergetic signaling in hepatotoxicity; metabolic dysfunction-associated steatotic liver disease (MASLD); alcoholic hepatitis; identification of therapeutic targets; cellular mechanisms of hepatotoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hepatotoxicity can be caused by drug medications, chemical agents, dietary supplements, solvents, and chronic alcohol drinking and leads to acute and chronic liver disease. Most DILIs improve after drug withdrawal. As the main organ that metabolizes and detoxifies chemicals, the liver is susceptible to these agents’ toxicity. Drug-induced liver injuries are dose-dependent; this form of liver injury is called predictable hepatotoxicity. In other cases, liver injury is caused by unpredictable (idiosyncratic) hepatotoxicity in susceptible individuals. Active signal transduction pathways and mitochondrial dysfunction are important in determining cell survival or death. Understanding the mechanisms and signal regulation in hepatotoxicity can aid in the production of therapeutic target molecules for safe and effective treatment.

This Special Issue on hepatotoxicity aims to collect and disseminate recent findings on the mechanisms, pathophysiology, and signal transduction pathways in hepatotoxicity and advancements in therapy. Original articles, communications, and review articles are welcome.

Dr. Sanda Win
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell death
  • reactive metabolites
  • oxidative stress
  • stress signaling
  • mitochondria
  • adaptive immunity
  • HLA associations
  • hepatotoxicity
  • drugs
  • liver injury
  • adverse drug reaction
  • drug-induced autoimmune hepatitis
  • idiosyncratic-drug-induced liver injury
  • bile acid
  • drug-induced cholestasis
  • hepatotoxins
  • steatosis
  • fibrosis

Published Papers (2 papers)

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Research

12 pages, 2796 KiB  
Article
Sesamin’s Therapeutic Actions on Cyclophosphamide-Induced Hepatotoxicity, Molecular Mechanisms, and Histopathological Characteristics
by Abdulmajeed M. Jali, Mohammad Firoz Alam, Ali Hanbashi, Wedad Mawkili, Basher M. Abdlasaed, Saeed Alshahrani, Abdullah M. Qahl, Ahmad S. S. Alrashah and Hamad Al Shahi
Biomedicines 2023, 11(12), 3238; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines11123238 - 07 Dec 2023
Viewed by 796
Abstract
Cyclophosphamide, an alkylating agent integral to specific cancer chemotherapy protocols, is often curtailed in application owing to its significant hepatotoxic side effects. Therefore, this study was conducted to assess the hepatoprotective potential of sesamin, a plant-originated antioxidant, using rat models. The rats were [...] Read more.
Cyclophosphamide, an alkylating agent integral to specific cancer chemotherapy protocols, is often curtailed in application owing to its significant hepatotoxic side effects. Therefore, this study was conducted to assess the hepatoprotective potential of sesamin, a plant-originated antioxidant, using rat models. The rats were divided into five groups: a control group received only the vehicle for six days; a cyclophosphamide group received an intraperitoneal (i.p.) single injection of cyclophosphamide (150 mg/kg) on day four; a sesamin group received a daily high oral dose (20 mg/kg) of sesamin for six days; and two groups were pretreated with oral sesamin (10 and 20 mg/kg daily from day one to day six) followed by an i.p. injection of cyclophosphamide on day four. The final and last sesamin dose was administered 24 h before euthanasia. At the end of the experiment, blood and liver tissue were collected for biochemical and histopathological assessments. The results indicated significantly increased liver markers (AST, ALT, ALP, and BIL), cytokines (TNFα and IL-1β), caspase-3, and malondialdehyde (MDA) in the cyclophosphamide group as compared to the normal control. Additionally, there was a significant decline in antioxidants (GSH) and antioxidant enzymes (CAT and SOD), but the sesamin treatment reduced liver marker enzymes, cytokines, and caspase-3 and improved antioxidants and antioxidant enzymes. Thus, sesamin effectively countered these alterations and helped to normalize the histopathological alterations. In conclusion, sesamin demonstrated the potential for attenuating cyclophosphamide-induced hepatotoxicity by modulating cytokine networks, apoptotic pathways, and oxidative stress, suggesting its potential role as an adjunct in chemotherapy to reduce hepatotoxicity. Full article
(This article belongs to the Special Issue Hepatotoxicity: From Pathology to Novel Therapeutic Approaches)
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19 pages, 2076 KiB  
Article
Effect of Quercetin Nanoparticles on Hepatic and Intestinal Enzymes and Stress-Related Genes in Nile Tilapia Fish Exposed to Silver Nanoparticles
by Mayada R. Farag, Haitham G. Abo-Al-Ela, Mahmoud Alagawany, Mahmoud M. Azzam, Mohamed T. El-Saadony, Stefano Rea, Alessandro Di Cerbo and Doaa S. Nouh
Biomedicines 2023, 11(3), 663; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines11030663 - 22 Feb 2023
Cited by 10 | Viewed by 2555
Abstract
Recently, nanotechnology has become an important research field involved in the improvement of animals’ productivity, including aquaculture. In this field, silver nanoparticles (AgNPs) have gained interest as antibacterial, antiviral, and antifungal agents. On the other hand, their extensive use in other fields increased [...] Read more.
Recently, nanotechnology has become an important research field involved in the improvement of animals’ productivity, including aquaculture. In this field, silver nanoparticles (AgNPs) have gained interest as antibacterial, antiviral, and antifungal agents. On the other hand, their extensive use in other fields increased natural water pollution causing hazardous effects on aquatic organisms. Quercetin is a natural polyphenolic compound of many plants and vegetables, and it acts as a potent antioxidant and therapeutic agent in biological systems. The current study investigated the potential mitigative effect of quercetin nanoparticles (QNPs) against AgNPs-induced toxicity in Nile tilapia via investigating liver function markers, hepatic antioxidant status, apoptosis, and bioaccumulation of silver residues in hepatic tissue in addition to the whole-body chemical composition, hormonal assay, intestinal enzymes activity, and gut microbiota. Fish were grouped into: control fish, fish exposed to 1.98 mg L−1 AgNPs, fish that received 400 mg L−1 QNPs, and fish that received QNPs and AgNPs at the same concentrations. All groups were exposed for 60 days. The moisture and ash contents of the AgNP group were significantly higher than those of the other groups. In contrast, the crude lipid and protein decreased in the whole body. AgNPs significantly increased serum levels of ALT, AST, total cholesterol, and triglycerides and decreased glycogen and growth hormone (*** p < 0.001). The liver and intestinal enzymes’ activities were significantly inhibited (*** p < 0.001), while the oxidative damage liver enzymes, intestinal bacterial and Aeromonas counts, and Ag residues in the liver were significantly increased (*** p < 0.001, and * p < 0.05). AgNPs also significantly upregulated the expression of hepatic Hsp70, caspase3, and p53 genes (* p < 0.05). These findings indicate the oxidative and hepatotoxic effects of AgNPs. QNPs enhanced and restored physiological parameters and health status under normal conditions and after exposure to AgNPs. Full article
(This article belongs to the Special Issue Hepatotoxicity: From Pathology to Novel Therapeutic Approaches)
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