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Biomedicines
Special Issues
Exploring Molecular Imaging in Animal Models
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Exploring Molecular Imaging in Animal Models

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 949

Special Issue Editor

Dr. Do-Wan Lee

E-Mail Website
Guest Editor
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea
Interests: chemical exchange saturation transfer; magnetic resonance spectroscopy; neuroimaging; molecular imaging; biomarker; diagnosis; translational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The objective of this Special Issue is to identify imaging biomarkers by observing qualitative and quantitative changes in specific neuro-metabolites within animal models of various diseases, utilizing advanced molecular imaging techniques such as chemical exchange saturation transfer (CEST), novel MR spectroscopy (MRS), positron emission tomography (PET), and optical imaging. Our aim is to comprehensively cover all aspects of novel neuro-biomarker findings and their validation, placing special emphasis on new approaches and the application of neuro-biomarkers in preclinical models.

We invite submissions of original research articles, review articles, brief communications, and comments focused particularly on established molecular imaging methods, with an emphasis on CEST, MRS, PET, and optical imaging.

Dr. Do-Wan Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical exchange saturation transfer
  • molecular diagnosis
  • advanced neuroimaging
  • biomarkers
  • preclinical models
  • positron emission tomography
  • novel MR spectroscopy
  • optical imaging

Published Papers (1 paper)

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Research

11 pages, 2605 KiB  
Article
Mapping Changes in Glutamate with Glutamate-Weighted MRI in Forced Swim Test Model of Depression in Rats
by Donghoon Lee, Chul-Woong Woo, Hwon Heo, Yousun Ko, Ji Sung Jang, Seongwon Na, Nari Kim, Dong-Cheol Woo, Kyung Won Kim and Do-Wan Lee
Biomedicines 2024, 12(2), 384; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines12020384 - 07 Feb 2024
Viewed by 714
Abstract
Chemical exchange saturation transfer with glutamate (GluCEST) imaging is a novel technique for the non-invasive detection and quantification of cerebral Glu levels in neuromolecular processes. Here we used GluCEST imaging and 1H magnetic resonance spectroscopy (1H MRS) to assess in [...] Read more.
Chemical exchange saturation transfer with glutamate (GluCEST) imaging is a novel technique for the non-invasive detection and quantification of cerebral Glu levels in neuromolecular processes. Here we used GluCEST imaging and 1H magnetic resonance spectroscopy (1H MRS) to assess in vivo changes in Glu signals within the hippocampus in a rat model of depression induced by a forced swim test. The forced swimming test (FST) group exhibited markedly reduced GluCEST-weighted levels and Glu concentrations when examined using 1H MRS in the hippocampal region compared to the control group (GluCEST-weighted levels: 3.67 ± 0.81% vs. 5.02 ± 0.44%, p < 0.001; and Glu concentrations: 6.560 ± 0.292 μmol/g vs. 7.133 ± 0.397 μmol/g, p = 0.001). Our results indicate that GluCEST imaging is a distinctive approach to detecting and monitoring Glu levels in a rat model of depression. Furthermore, the application of GluCEST imaging may provide a deeper insight into the neurochemical involvement of glutamate in various psychiatric disorders. Full article
(This article belongs to the Special Issue Exploring Molecular Imaging in Animal Models)
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