Gut Microbiota and Host Mitochondria Crosstalk in Health and Disease

Dear Colleagues,

Gut dysbiosis is crucial in the development of different pathological conditions including, but not limited to, cardiovascular disease, metabolic syndrome, neurological disorders, and cancer. Interestingly, a connection between gut microbiota (GM) and mitochondria has been suggested over the last few years. In particular, GM has been demonstrated to affect mitochondrial function by regulating crucial transcription factors, coactivators, as well as enzymes implicated in mitochondrial biogenesis and metabolism. Moreover, GM-derived metabolites have been shown to interfere with mitochondrial oxidative/nitrosative stress and autophagosome formation, thus influencing the activation of the inflammasome and the production of inflammatory cytokines, which are key players in several disease states. However, the full elucidation of the underlying mechanisms requires further investigation.

This Special Issue will cover a selection of recent research topics related to the role of GM in health and disease with a special focus on the effects of GM-derived metabolites in the modulation of mitochondria homeostasis and quality control under physiological and pathological condition. Topics on therapeutic strategies for gut microbiota modulation (e.g., probiotic, prebiotic, and symbiotic treatments, as well as fecal microbiota transplantation), which aim to rescue host mitochondrial function in disease conditions, are encouraged. Up-to-date original basic, preclinical, and clinical researches, as well as reviews and commentaries, are also welcomed.

Dr. Francesca Forini
Dr. Letizia Guiducci
Guest Editors

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• gut microbiota
• gut microbiota-derived metabolites
• dysbiosis
• mitochondria quality control
• mitochondrial function
• cardiovascular disease
• metabolic disease
• nervous system disorders
• cancer