Lipid and Cholesterol Metabolism in Health and Disease: A Focus on the Cross-Talk between Peripheral Tissues and Central Nervous System
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 6907
Special Issue Editor
Interests: metabolic syndrome; NAFLD/MAFLD; cross-talk between peripheral and central metabolism of glucose and lipids; diabetic cardiomyophaty; natural antioxidants; nutraceuticals and pharmacotherapy; oxidative stress; inflammation
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Special Issue Information
Dear Colleagues,
Cholesterol plays a fundamental role in the human body, as it is an essential component of all cell membranes, the precursor of steroid hormones and bile acids—which are necessary for the intestinal absorption of cholesterol, fats and lipophilic vitamins. Moreover, at the central nervous system (CNS) level, cholesterol contributes to maintaining physiological brain function. Cholesterol can be obtained through diet and through endogenous synthesis. Its homeostasis depends on a complex equilibrium deriving by its ingestion, absorption, synthesis and excretion mediated by lipoprotein trafficking. In this view, the correct metabolism of lipids also contributes to ensure key physiological functions.
On the other hand, the alteration of cholesterol and lipid homeostasis represents a major risk for metabolic and cardiovascular disorders, whereas at the CNS level, its impairment appears to be involved in several neurological diseases, such as Alzheimer’s and Parkinson’s diseases, Niemann–Pick C disease and depression. Moreover, although cholesterol metabolism in peripheral tissues is independent from metabolism in the brain due to the blood–brain barrier, the crosstalk between central and peripheral lipid metabolism still remains an underestimated item in both physiological and pathological conditions.
Consequently, the main purpose of this Special Issue is to shed new knowledge on the possible connections between peripheral and central metabolism of lipid and cholesterol metabolism to identify possible novel targets aimed to develop a therapeutic strategy to counteract detrimental effects of their dysregulation in chronic diseases.
Potential topics include but are not limited to the following:
- Physiological role of cholesterol and lipids:
- Structural role in membranes;
- LDL and HDL trafficking;
- Hormone synthesis (central and peripheral steroids);
- Bile acids and vitamins.
- Cholesterol/lipid metabolism and cardiovascular system.
- Cholesterol/lipid metabolism in the brain.
- Role of altered cholesterol/lipid metabolism in the enhancement of cardiometabolic risk (i.e., metabolic syndrome, diabetes, cardiomyopathies, skeletal muscle impairment and heart failure).
- Cholesterol/lipid metabolism dysregulation in neurological diseases (i.e., behavioural diseases and cognitive function dysregulation).
- The crosstalk between peripheral and central cholesterol/lipid metabolism in health and diseases (i.e., role of free radicals, mediators of inflammation, oxysterols, free fatty acids and miRNAs).
- Novel therapeutic approaches in the treatment of altered cholesterol/lipid metabolism (conventional drugs, nutraceuticals and innovative drugs).
Dr. Micaela Gliozzi
Guest Editor
Manuscript Submission Information
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