Current Concepts of Osteoarthritis—from Pathogenesis and Prevention to Diagnosis and Treatment

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 843

Special Issue Editor


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Guest Editor
Children’s Orthopaedics Department, Medical University of Lublin, Lublin, Poland
Interests: spine; scoliosis; pediatric orthopaedics; osteogenesis; growth factors

Special Issue Information

Dear Colleagues,

As we age, our joints may feel the wear and tear of a lifetime of use. Osteoarthritis, as a debilitating condition, affects millions of people worldwide. It causes pain, stiffness, and limited mobility. However, with proper diagnosis, prevention, and treatment, managing the condition and improving the overall quality of life is possible.

We invite contributors to participate in our Special Issue on Osteoarthritis. This Special Issue aims to summarize the current state of the art in the Osteoarthritis field and highlight the recent advancements in diagnosis, prevention, pathogenesis, and treatment.

In this Special Issue, authors will have the opportunity to share:

  1. The latest research and insights regarding the diagnosis of Osteoarthritis, including imaging, biomarkers, and clinical examination to identify the condition earlier. 
  2. Prevention strategies to slow down the progression of the disease, highlighting potential pharmacological effects. 
  3. Research on the pathogenesis of Osteoarthritis, including potential mechanisms that may contribute to the development of the condition. 

Given the high prevalence of Osteoarthritis, we urge potential contributors to submit their papers to this Special Issue to advance the knowledge and capabilities of this field. We look forward to receiving submissions from experts in the field to improve patient care and treat this chronic disease.

Dr. Michal Latalski
Guest Editor

Manuscript Submission Information

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Keywords

  • osteoarthritis
  • articular cartilage
  • chondrocyte
  • subchondral bone
  • synovial membrane
  • synovial fluid
  • muscle
  • meniscus
  • pathogenesis
  • biomarkers

Published Papers (1 paper)

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Review

23 pages, 699 KiB  
Review
Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights
by Shunichi Yokota, Hotaka Ishizu, Takuji Miyazaki, Daisuke Takahashi, Norimasa Iwasaki and Tomohiro Shimizu
Biomedicines 2024, 12(4), 843; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines12040843 - 11 Apr 2024
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Abstract
The increased incidence of osteoarthritis (OA), particularly knee and hip OA, and osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, and the involvement of subchondral bone fragility spotlights its association with OP. [...] Read more.
The increased incidence of osteoarthritis (OA), particularly knee and hip OA, and osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, and the involvement of subchondral bone fragility spotlights its association with OP. Notably, subchondral insufficiency fracture (SIF) may represent a more pronounced condition of OA pathophysiology. This review summarizes the relationship between OA and OP, incorporating recent insights into SIF. Progressive SIF leads to joint collapse and secondary OA and is associated with OP. Furthermore, the thinning and fragility of subchondral bone in early-stage OA suggest that SIF may be a subtype of OA (osteoporosis-related OA, OPOA) characterized by significant subchondral bone damage. The high bone mineral density observed in OA may be overestimated due to osteophytes and sclerosis and can potentially contribute to OPOA. The incidence of OPOA is expected to increase along with population aging. Therefore, prioritizing OP screening, early interventions for patients with early-stage OA, and fracture prevention measures such as rehabilitation, fracture liaison services, nutritional management, and medication guidance are essential. Full article
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