Microcirculation, Thrombosis, and Inflammation in Peripheral Artery Disease and in the Brain

Dear Colleagues,

Peripheral artery disease is, to a wide extent, driven by chronic inflammatory and prothrombotic signaling pathways. Vascular dysfunction underlies the progression of atherosclerosis and macrovascular as well as microvascular alterations. Moreover, pro-inflammatory signaling pathways are supposed to be a link between atherosclerotic and neuropsychological diseases. The same inflammatory pathways, especially proinflammatory cytokines, are also discussed as potential factors for alterations in synaptic plasticity, signal intensity, and functional connectivity of the brain, with a potentially important role for the microglia. The difference is that in neuroinflammation, no broad invasion into tissue or tissue destruction takes place. Instead, functional connectivity problems or neurotransmitter alterations, for example, lead to clinically similar pictures as psychic alterations due to artery disease. Only precise differentiation in clinical diagnosis, e.g., concerning affect regulation problems, helps to differentiate and provide proper treatment. This Special Issue invites us to dig into the biomedical exploration of these differentiations and enrich the bio-psycho connection. We welcome articles focusing on peripheral artery disease, including vascular dysfunction, thrombosis, and inflammation, with a special focus on the context of systemic secretion of chemokines and neurotransmitter alterations.

Dr. Patricia Pia Wadowski
Guest Editor

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• microcirculation
• thrombosis
• inflammation
• peripheral artery disease
• brain