Endometrial Cancer: From Pathobiology to Treatment

Dear Colleagues,

Endometrial cancer (EC) is the fifth most common cancer in women worldwide. Global estimates show rising incidence rates in both developed and developing countries. The utilization and choice of ART for patients interested in fertility preservation depends on the type and stage of cancer, the treatment plan, the time available until the cancer treatment has to start, and whether the patient has a committed partner. For patients who have a committed male partner, embryo cryopreservation has a long track record of being a very successful procedure for fertility preservation. A fertility-sparing approach for grade 1 endometrioid adenocarcinoma limited to the endometrium is feasible and can be considered in premenopausal patients with plans to conceive in the near future. Fertility-sparing treatment predominantly involves the use of oral progestins and levonorgestrel-releasing intrauterine devices, which have been shown to be feasible and safe in women with early stage EC and minimal or no myometrial invasion.

This Special Issue aims to provide an update about the current state of the art in the diagnosis management, treatment and outcomes of endometrial cancer in reproductive age regarding fertility, from basic science to translation approach.

Topics of interest for this Special Issue include, but are not limited to, the following：

• Etiology and pathogenesis of endometrial cancer in fertile women;
• Biomolecular and genetic prognostic factors of endometrial cancer (EC);
• Fertility-sparing approach in EC;
• Oocyte vitrification and fertility preservation;
• Stem cells as therapy for EC;
• Fertility preservation approach in women affected by endometriosis.

Dr. Giuseppe Gullo
Dr. Gaspare Cucinella
Dr. Valentina Billone
Guest Editors

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• endometrial cancer
• fertility preservation
• ovarian reserve