Molecular Research on Biofilm Formation
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 186
Special Issue Editor
Interests: intrinsically disordered proteins; protein folding; protein misfolding; partially folded proteins; protein aggregation; protein structure; protein function; protein stability; protein biophysics; protein bioinformatics; conformational diseases; protein–ligand interactions; protein–protein interactions; liquid-liquid phase transitions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biofilms are immobile microbial communities that represent 3D agglomerations of microorganisms, in which bacteria are adhered to each other and to a surface by means of a self-produced matrix of bacterial secreted extracellular polymeric substances, such as exopolysaccharides (EPS), extracellular DNA (e-DNA), proteins and amyloidogenic proteins. Such biofilms represent highly pliable systems that allow their inhabitants to adapt to environmental conditions and tolerate antibiotics, host defense systems, and other external stresses, such as desiccation, nutrient scarcity, mechanical and shear forces, osmolarity, and pH. Biofilms are formed via a set of well-regulated multi-step events, and cell-to-cell communication, signaling, and coordination within the biofilm are conducted via quorum sensing, where the regulation of the expression of specific genes is driven by the accumulation of signaling molecules in the extracellular environment. Biofilms are related to the pathogenesis of biofilm diseases in the auditory, cardiovascular, digestive, integumentary, reproductive, respiratory, and urinary systems. Furthermore, bacterial biofilms play crucial roles in antimicrobial resistance. Therefore, understanding the peculiarities of biofilm biogenesis is crucial for the development of effective treatment strategies for such infections.
Prof. Dr. Vladimir N. Uversky
Guest Editor
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Keywords
- biofilm
- extra-cellular matrix
- extracellular polymeric substances
- extracellular DNA
- exopolysaccharides
- quorum sensing
- wound infections
